OBJECTIVE To estimate the prevalence of multiple sclerosis in the L'Aquila district, central Italy. METHODS All available case sources were screened. Definite and probable cases of multiple sclerosis, classified according to the Poser criteria, were considered as prevalent cases. RESULTS On the prevalence day, 31 December 1996, 158 patients (105 women and 53 men; ratio 2:1) affected by defi...

BACKGROUND We aimed to determine the association of clinical and routine cerebrospinal fluid biochemical markers (total protein, IgG index and oligoclonal bands) with disability in multiple sclerosis and whether these biomarkers assessed at diagnosis add prognostic value. METHODS We followed a cohort of patients included in the Multiple Sclerosis Lorraine Register (eastern France) who had a d...

vitamin d has long been speculated to reduce the risk of multiple sclerosis (ms). however, its role in development and modulating the course of ms has yet to be clarified. to date, there is no scientific evidence for the use of vitamin d as monotherapy for ms in clinical practice and perplexities still exist on potential disadvantages of vitamin d intake. we hypothesize that vitamin d may be ef...

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background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

background: there has been a global rising trend in recent years in the incidence of multiple sclerosis (ms). despite being an ms low-risk region, this disease has also been recently on the rise in the middle east. as part of the middle east, iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. the present study reviews possible reasons for thi...

conclusions the orem-based self-care model program can be a useful tool to improve sleep quality of patients with ms. future studies can be directed to investigate the effects of such interventions on other common problems of patients. results before the intervention, there was no significant difference between the two groups with regard to mean scores of sleep quality (p = 0.22). both groups r...

multiple sclerosis (m.s) is one of the prevalent diseases of the central nervous system which cause disability in young adults. this appears as neural signs in different parts and various times. the main defect is local deterioration or destruction of myelin tissue in the brain and spinal cord. profound fatigue is one the most common symptoms of this disease. because ms is prevalent in middle a...