OBJECTIVE To validate the effect of gender on age at onset of schizophrenia in a developing country. METHODS Medical records of 252 patients diagnosed with schizophrenia according to DSM-IV criteria at a tertiary care hospital in Karachi, Pakistan between 2002 and 2008 were reviewed using a structured questionnaire. Age at onset was defined as age at onset of psychotic symptoms, age at first ...

The issue of neurodegeneration in schizophrenia is controversial. Although most studies indicate that neurocognitive deficits are relatively stable over the course of the illness, conclusions are limited by relatively short follow-up periods and absence of age-matched control groups. Furthermore, nearly all studies deal with adult-onset schizophrenia, and few studies have considered the possibl...

• Brain function is abnormal in adolescents with schizophrenia. Adolescent schizophrenia can be recognized based on brain function. The early onset of associated dysfunction. This study aimed to investigate the alterations causal connectivity between regions Adolescent-onset (AOS) patients. Thirty-two first-episode drug-naïve AOS patients and 27 healthy controls (HC) were recruited for resting-...

BACKGROUND Patients with schizophrenia or bipolar disorder (BPD) may be differentially sensitive to antipsychotics. This study assessed the median time to onset, duration, and rate of somnolence associated with asenapine and other antipsychotics in both indications. METHODS Ten clinical trials (n = 4786) were analyzed as five cohorts pooled according to indication and study design. RESULTS ...

After graduating from University of Tsukuba in 1982, I joined the Department Psychiatry at same university. Due to anti-psychiatry social movement and reports incidents involving violence against in-hospital patients psychiatric hospitals, associations Japan faced questions related ethical awareness, making it a challenging environment for conducting clinical research. For this reason, first ha...

MAIN RESULTS People with a history of epilepsy were about two to three times more likely to develop schizophrenia or schizophrenia-like psychosis than people who had never had epilepsy (see http://www.ebmental health.com/supplemental for table). This effect did not differ according to type of epilepsy. The later the onset of epilepsy the greater the increase in risk of psychosis (schizophrenia ...