CONTEXT Pseudohypoparathyroidism type Ib (PHP-Ib) is a rare disorder resulting from genetic and epigenetic aberrations in the GNAS complex. PHP-Ib, usually defined by renal resistance to parathyroid hormone, is due to a maternal loss of GNAS exon A/B methylation and leads to decreased expression of the stimulatory G protein α (Gsα) in specific tissues. OBJECTIVE To clarify the usefulness of m...

The relationship between the (open-loop) optimization problem that is repeatedly solved online and the quality of the (closed-loop) schedule that is implemented, is poorly understood, even in the deterministic case. We investigate various attributes of the open-loop problem and the rescheduling algorithm that affect the quality of closed-loop schedules, viz. rescheduling frequency, scheduling h...

The process of craft file design and management, which varies a lot in different areas and enterprises, is the most important part of design process in Small and Middle-sized Manufacturing Enterprises (SMMEs). The Design and Management System of such processes is required to be highly customized due to their complexity and lack of flexibility. In this paper, we presented a simple SMMEs oriented...

This paper presents a discussion of the current trends in the implementation of Learning Content Management Systems (LCMSs) and provides a working definition of the features that should be provided by such systems. Thus, after discussing a new structure of Learning Objects in the framework of Metacognition to implement significant learning, it shows how an open source Content Management System ...

Introduction. Primary hyperparathyroidism (PHP) is characteristically determined by high levels of calcium and high or inappropriate levels of parathyroid hormone (PTH). Technological advances have dramatically changed the surgical technique over the years once intraoperative parathyroid hormone (IOPTH) assay had allowed for focused approaches. Objective. To evaluate our 10-year experience in e...

Primary hyperparathyroidism (PHP) affects 0.5%-1% of the adult population and presents with classical signs of renal lithiasis, cholecystolithiasis, gastrointestinal ulcerations, depression, and osteoporosis. Parathyroid adenoma, hyperplasia and rarely carcinoma are the underlying pathology. Synchronous thyroid and parathyroid pathologies are described in multiple endocrine neoplasia. We report...