vision and then adopted after an extensive design process. OISD may serve to be a more powerful model of change in that it capitalizes on powerful system concepts such as positive feedback and key leverage points, while still retaining a pragmatic orientation. The six phases of OISD are described below. The phases are loose and overlapping; they naturally would probably occur in sequential orde...

becoming increasingly common for transitions to also include moving between regular and alternative placements. Many high schools rely on an alternate placements as a means of dealing with disruptive students. ere is also a subcategory of placements for students who have a disability. Appropriate transitions in each of these demanding situations is essential to keep the placement from becoming ...

mtcPTM is an online repository of human and mouse phosphosites in which data are hierarchically organized to preserve biologically relevant experimental information, thus allowing straightforward comparisons of phosphorylation patterns found under different conditions. The database also contains the largest available collection of atomic models of phosphorylatable proteins. Detailed analysis of...

Sir.?The aims of your paper in regard to the public health, as set out in your New Year's issue, are excellent. And as everyone seems to be waking up at last to the fact that the housing question overshadows every other question in domestic politics, perhaps something will be accomplished. Questions of housing and health must not, however, be allowed to become the playthings of politics. Every ...

Therapeutic Area: Ophthalmology Inflammatory diseases of the ocular surface, including allergic conjunctivitis (AC) Mechanism of action: Anti-inflammatory and immuno-modulator Planned indication: Treatment of signs and symptoms of allergic conjunctivitis Patent protection: License from Zalicus, Patents expire in November 2026 (without patent extension) US: patented EU: patent pending Route of a...

As the title of this introduction implies, there are few traces of hope and optimism to be found in Haiti’s current situation. If the unavoidable problems of rural communities in a nation of peasants such as Haiti are left unaddressed, and if the nation continues to rely on the standards of the old police state as a model for the new national police, Haiti’s transition toward democracy will be ...

The provision of multi-organizational time-critical services requires integrated data exchange across partners, but achieving this technical goal requires sustained and comprehensive attention to inter-organizational relationships and governance mechanisms. This article first describes a general framework that captures the requirements for multi-organizational collaboration for different time-c...