conclusions most patients are referred for restaging and demonstrate evidence of regional or distant metastasis with significant value for further treatment planning. providing insurance coverage and familiarizing referring physicians about appropriate indications of this relatively new diagnostic modality will be to the best interest of head and neck cancer patients in long term. methods we re...

xx Signed statement xxv Acknowledgements xxvi

Surgery is the mainstay of treatment in ca buccal mucosa. It extensive nature and may require efficient reconstruction for good cosmetic outcome. Adjuvant radiation or chemo-radiation be needed advanced cancers. Definitive chemoradiation palliative are reserved inoperable patients. We present a case report carcinoma oral cavity left mucosa along with involvement retromolar trigone bone sided ma...

Despite considerable progress in the prevention, detection, and treatment of several cancers, most oral squamous cell carcinomas are detected in the advanced stages. In addition, the multistep process of oral oncogenesis involving accumulation of genetic alterations is complex and not yet fully understood. This short review focuses the current understanding oral oncogenesis, biomarkers, chemopr...

Oral cancer makes up 1%-2% of all cancers that may arise in the body. The majority of oral cancers consists of squamous cell carcinomas. Oral cancer carries a considerable mortality rate, being mainly dependent on the stage of the disease at admission. Worldwide some 50% of the patients with oral cancer present with advanced disease. There are several ways of trying to diagnose oral cancer in a...

The head and neck region consists of subsites, including the oral cavity, pharynx, larynx, nasal sinuses, salivary glands, and orbits, and contains important organs performing functions that are directly related to the Quality of Life (QOL), such as chewing, swallowing, and phonation. It has been reported that 32% of head and neck cancers occur in the oral cavity, 24% in the larynx, 35% in the ...

BACKGROUND The prognostic utility of comorbidity on head and neck cancer may differ by subsite, stage, and human papillomavirus (HPV) status. METHODS We reviewed the medical records of 4953 patients with head and neck cancer for comorbidity (Charlson Comorbidity Index [CCI]), smoking, and alcohol history. Multivariate proportional hazards assessed the association of CCI with survival. HPV sta...

Oral health problems are among the most common chronic health conditions experienced by older adults. Healthy People 2000, an initiative to improve the health of America, has selected oral health as a priority area. l About 11 of 100,000 persons have oral cancer diagnosed every year.2 The average age at which oral cancer is diagnosed is approximately 65 years, with the incidence increasing from...

PURPOSE To determine the maximum tolerated dose and dose-limiting toxicity of Doxil with low-dose continuous infusion topotecan and subsequently with low-dose oral topotecan. Other specific aims were preliminary assessment of activity in advanced ovarian and tubal malignancies, pharmacokinetics of oral topotecan, and correlation of response with topoisomerase I and II expression in tumors. ME...

Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads re...