OBJECTIVES/HYPOTHESIS The incidence of occult perifacial nodal disease in oral cavity squamous cell carcinoma is not well reported. The purpose of this study was to evaluate the incidence of isolated perifacial lymph node metastasis in patients with oral squamous cell carcinoma with a clinically node-negative neck. The study will shed light on current controversies and will provide valuable cli...

Many types of cancers develop in the oral and maxillofacial region. Squamous cell carcinoma is the most common cancer and constitutes over 90 percent of these tumors. Malignant transformation is a genetic process, which later makes a phenotyping change at the cellular level. Some cancers such as oral squamous cell carcinomas (OSCCs) develop from pre-malignant lesions and conditions. Despite adv...

The oral cancer is one of the most prevalent type of cancer worldwide. It is invariably linked to lifestyle habits like alcohol consumption, cigarette smoking and poor nutritional status. This apart, the role of micronutrients in oral carcinogenesis still remains less understood. So the study was undertaken to assess the micronutrient levels of oral cancer and precancerous patients.The estimati...

UNLABELLED Currently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. AIM The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. MATERIALS AND METHODS Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed b...

In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with (1)H NMR, (13)C NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carc...

BACKGROUND To determine the frequency of various histologic types of primary solid malignant neoplasms in males and females, in our practice, in a large series of surgical biopsies. METHODS A retrospective study of 20,000 consecutive surgical biopsies in the section of Histopathology, Aga Khan University Hospital (AKU), Karachi, in 2004. RESULTS Squamous cell carcinoma of oral cavity was th...

BACKGROUND Worldwide, oral squamous cell carcinoma (potentially mediated by HER2) is recognized as the most commonly occurring malignant neoplasm of the oral cavity. Anti-HER2 nanobodies conjugated to gold-silica nanoshells and used as photothermal treatment for oral squamous cell carcinoma may provide a novel therapeutic alternative to current treatment for this disease. METHODS KB epithelia...

Oral verrucous carcinoma (VC) is a rare locally invasive tumor. The histopathological diagnosis of verrucous carcinoma should be accompanied with careful identification of tumors with a greater chance to become frank cancers. A comprehensive Google and PubMed search was carried out using “oral, verrucous carcinoma and immunohistochemistry” as the key searching terms. All the articles till date ...

AIM Altered lipid profile patterns have been associated with malignancies because lipids play a pivotal role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in oral squamous cell carcinoma patients as well as its association with the habit of tobacco consumption. MATERIALS AND METHODS The study included 30 oral squamous cell carcinoma patie...

ABSTRACT Background: The oral squamous cell carcinoma (OSCC), the most common malignant tumor of cavity, have aggressive biological behavior and is treated with surgical excision, lymph node dissection submandibular gland excision. However, rarely involved by OSCC. study aimed to identify prevalence involvement metastasis in cavity patients at a tertiary care center Pakistan. Methods: cancer (1...