نتایج جستجو برای: oral etoposide
تعداد نتایج: 265365 فیلتر نتایج به سال:
Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating wide variety tumors. However, ETP induced hepatotoxicity nephrotoxicity limits its clinical use. This study aims to investigate protective potential taurine (Tau) mitigated histopathological changes in liver kidneys female albino rats treated with ETP. A total 18 were divided into t...
The Bcl-2 protein is known to exert not only anti-apoptotic but also anti-autophagic activities. Numerous studies have demonstrated that etoposide, which is one of the most widely used cancer chemotherapy agents, induces apoptotic cell death. However, the exact molecular mechanism leading to cell death by etoposide remains to be resolved. This study aimed to dissect the mode of cell death induc...
We previously reported that exposure of human colon adenocarcinoma (Caco-2) cells to the bitter substance phenylthiocarbamide (PTC) rapidly enhanced transport function P-glycoprotein (P-gp). In this study, we investigated short-term effect etoposide, another bitter-tasting P-gp substrate, on in same cell line. found etoposide significantly increased both protein level plasma membrane fraction a...
Protein kinase Cdelta (PKCdelta) is involved in the apoptosis of various cells in response to diverse stimuli. In this study, we characterized the role of PKCdelta in the apoptosis of C6 glioma cells in response to etoposide. We found that etoposide induced apoptosis in the C6 cells within 24 to 48 h and arrested the cells in the G(1)/S phase of the cell cycle. Overexpression of PKCdelta increa...
BACKGROUND AND THE PURPOSE OF THE STUDY Etoposide is an antineoplastic agent used in multiple cancers. It is known that etoposide induce cell death via interaction with topoisomerase II; however, the etopoisde cellular response is poorly understood. Upon etoposide induced DNA damage, many stress signaling pathways including JNK are activated. In response to DNA damage, it has been shown that WW...
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