Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with drug transport may alter the kinetics of drug substrates. In vitro and in vivo studies indicate ...

Nanospheres are being developed for the oral delivery of peptide-based drugs such as insulin. Mucoadhesive, biodegradable, biocompatible, and acid-protective biomaterials are described using a combination of natural polyelectrolytes, with particles formulated through nanoemulsion dispersion followed by triggered in situ gel complexation. Biomaterials meeting these criteria include alginate, dex...

Severe GH deficiency (GHD) in adults has been described as a clinical entity. However, some of the features associated with GHD could be due to unphysiological and inadequate replacement of other pituitary hormone deficiencies. This may be true for glucocorticoid replacement that lacks a biomarker making dose titration and monitoring difficult. Moreover, oral estrogen replacement therapy decrea...

Atrial Fibrillation (AF) is the most common dysrhythmia seen in primary care. Thromboembolic stroke remains one of the most feared complications of this rhythm disturbance. Five landmark trials have demonstrated the efficacy of warfarin and aspirin in reducing this risk. Warfarin use is known to be labor intensive for patients and concerns regarding multiple drug interactions and bleed risk hav...

evaluation of periodontal status by cpitn among (35-44) – year – old population in khoramabad (2002) dr. f. haghighati* - dr. sh. salehi** - dr. r. valizadeh*** * - associate professor of periodontics dept. - faculty of dentistry – tehran university of medical sciences. **-assistant professor of periodontics dept. - faculty of dentistry – tehran university of medical sciences. ***- dentist. bac...

introduction: multiple myeloma is a neoplasm of monoclonal plasmacells which may cause oral manifestations. we report a 50-year-old man with a mass burned out of a post extraction socket. he had recived an eight month period of chemotherapy and was supposed to be ready for hematopoetic stem cell transplantation. after clinical and histopathological examinations, the mass was diagnosed as a plas...

The human microbiome plays a crucial role in health and disease conditions. These microbiomes constitute structured, coordinated microbial network throughout the body. oral cavity harbors one of extensively diverse bacteria system. Although many studies emphasize bacteriome its interaction with host system, very little attention is given to candidate phyla radiation (CPR), fungal components, in...