Ventricular tachycardia is unusual in infancy. Three infants are described in whom this arrhythmia was documented by electrophysiologic studies. The ability to start and terminate this rhythm by critically timed premature ventricular stimulation suggests a reentrant mechanism. All three patients have remained free of arrhythmias on oral propranolol therapy.

An 8-week-old infant was treated with oral propranolol for a haemangioma of infancy. The standard dose (according to protocol) is 2 mg/kg/day but, because of a mistake by the pharmacist, the child was treated with 8 mg/kg/day without any side effects (pulse, blood pressure and glucose stayed normal).

Lack of effect of propranolol and metoprolol on glucose tolerance in maturity-onset diabetics Although the effect of beta-blocking drugs on the response to hypo-glycaemia has been extensively studied, less attention has been paid to the possibility that they might cause deterioration of glucose tolerance. Release of insulin is stimulated by beta-agonists, and two studies have shown that infusio...

tion. Clin Chem 25: 777, 1979 16. Snedecor GW, Cochran WG: Statistical Methods. 6th ed. Ames, Iowa, Iowa State University Press 1967, p 308 17. Leon MB, Rosing DR, Bonow RO, Lipson LC, Epstein SE: Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris. Am J Cardiol 48: 131, 1981 18. Johnson SM, Mauritson DR, Corbett JR, Woodwa...

The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1.5 mg/kg/day to 22 infants with proliferating hemangiomas in the Department of Oral and Maxillofacial Surgery (Hospital of Stomatology, China Medi...

nolol is essentially complete, and no metabolism of this drug occurs in the gut. After the oral administration of propranolol, the liver is the principal site of extensive pre-systemic and systemic metabolism, and less than 1% of the intact drug is found in the urine. However, Bianchetti et al. showed that the area under the concentration–time curve for orally administered propranolol in renal ...