Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug ...

BACKGROUND Feedback delivery is deemed as a key element during a students' clinical education. It keeps students on track to meet their goal and increase students' motivation and confidence. OBJECTIVE The aim of this study was to compare the quality of feedback delivery in oral versus written feedback delivery to nursing students in clinical education. METHODS A randomized controlled trial ...

Objectives: This study aimed to assess the components of oral health care system in some developed countries and propose a model for Iran   Methods: The present study was a qualitative, cross-sectional, and comparative research that took place in 2012. Oral health care systems in some developed countries were reviewed to propose a framework for Iran. This framework was discussed and revie...

The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects owing to increased patient compliance. Unfortunately, the oral delivery route is beset with problems such as gastrointestinal (GI) destruction of labile molecules, low levels of macromolecular absorption, etc. To reduce the impact of digestive enzymes and to ensure the absorption of bioactive agents in...

INTRODUCTION Dental caries pose distinct challenges when it comes to determining their microbial etymology. Streptococcus mutans play an important role in dental caries. The aim of the present study was to compare oral microbiota in infants delivered by these different routes. A study was conducted on 40 infants. Swab sample collection was done for the detection of S. mutans. Our study indicate...

BACKGROUND Disulfide-linked oligodeoxyribonucleotide (ODN) liposomes were formulated and evaluated for the delivery of antisense ODN G3139 in KB human oral carcinoma cells. MATERIALS AND METHODS Liposomes composed of 1,2-di-(9Z-octadecenoyl)-3-trimethylammo-nium-propane (DOTAP)/egg phosphatidylcholine/alpha-tocopheryl polyethylene glycol 1000 succinate were incorporated with hydrophobized dis...

Live attenuated Salmonella strains have been extensively explored as oral delivery systems for recombinant vaccine antigens and effector proteins with immunoadjuvant and immunomodulatory potential. The feasibility of this approach was demonstrated in human vaccination trials for various antigens. However, immunization efficiencies with live vaccines are generally significantly lower compared to...

Oral route is the most common and convenient route for drug delivery, but some drugs are not given by this route. This route is most common problem is low bioavailability .The various challenges faced by the pharmaceutical scientists leads to the improve bioavailibilityty enhance the approach of self emulsifying drug delivery system. It has gained exposure of their ability to increase solubilit...

Nowadays the development of new drug delivery systems plays a major role in pharmaceutical industries. The drug delivery practice has been altered in last years and even many advanced innovations happened in recent times. Newer drug delivery technologies are largely influencing the current medical practice. Alterations of a current drug into a new drug delivery technology can positively changin...