Aim. The choice of the qualitative and quantitative composition excipients to provide required mechanical strength disintegration time when developing a pharmaceutical in form orally disintegrating tablets (ODT) based on paracetamol N-acetyl-D-glucosamine. Materials methods. study object was pharmaceutically accepted used development solid dosage forms. To conduct statistical analysis experimen...

Citrus kawachiensis peel (PCK), a new functional food material, may prolong the healthy life expectancy of aging populations. Tableting PCK could facilitate its worldwide distribution and consumption. A dosage form that is easy to swallow should be prepared for ease use by elderly. We investigated fabrication orally disintegrating (OD) tablets with required commercial strength disintegration ti...

In clinical practice, a thickening solution is frequently coadministered with medicinal tablets to facilitate swallowing by older patients. This study investigated the effect of solutions on reduction in drug dissolution from orally disintegrating (ODTs) testing disintegrant-free ODT, Molded Tablet (MT), and various disintegrant-containing ODTs. After measurement tensile strength test ODTs, was...

orally disintegrating tablets (odts) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. the aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

Scopolamine hydrobromide (SH)-loaded microparticles were prepared from a colloidal fluid containing ionotropic-gelated chitosan nanoparticles using a spray-drying method. The spray-dried microparticles were then formulated into orally disintegrating tablets (ODTs) using a wet granulation tablet formation process. A drug entrapment efficiency of about 90% (w/w) and loading capacity of 20% (w/w) ...

Article history: Received on: 13/08/2014 Revised on: 09/09/2014 Accepted on: 15/10/2014 Available online: 27/11/2014 Desloratadine (DS) is a tricyclic antihistaminic, characterized by bitter taste and slight water solubility. The aim of this study is to prepare DS as orally disintegrating tablets (ODT) to mask the bitter taste and improve compliance. Twelve different placebo ODT (F1-F12) were p...