During the course of my research in asymmetric organocatalysis, inversion enantioselectivity was observed aldol reactions acetone with different aldehydes catalyzed by amphiphilic proline derivatives aqueous media varying only achiral components. It not possible to explain explored dual stereocontrol existing models, therefore I proposed a new mechanism for l-amino acid and explained phenomenon...

Recent advances in both experimental and computational techniques pose an exciting time for chemistry. Computational tools traditionally used to interpret trends have now evolved into predictive models able guide the design of novel catalysts. This review discusses evolution these models, as well challenges future avenues field organocatalysis. Through representative examples we demonstrate how...