نتایج جستجو برای: orthopedic implant

تعداد نتایج: 61032  

2016
Xiangning Liu Ye Zhang Shaobing Li Yayu Wang Ting Sun Zejian Li Lizhao Cai Xiaogang Wang Lei Zhou Renfa Lai

New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in t...

2014
Wei Song

DEVELOPMENT AND APPLICATION OF BIOMIMETIC ELECTROSPUN NANOFIBERS INTOTAL JOINT REPLACEMENTbyWEI SONGMay 2014Advisor: Dr. Weiping RenMajor: Biomedical EngineeringDegree: Doctor of Philosophy Failure of osseointegration (direct anchorage of an implant by bone formation at the bone‐implant surface) and implant infection (such as that caused by Staphylococcus aur...

2011
Cristiane Machado Mengatto Federico Mussano Yoshitomo Honda Christopher S. Colwell Ichiro Nishimura

BACKGROUND Successful dental and orthopedic implants require the establishment of an intimate association with bone tissue; however, the mechanistic explanation of how biological systems accomplish osseointegration is still incomplete. We sought to identify critical gene networks involved in osseointegration by exploring the implant failure model under vitamin D deficiency. METHODOLOGY Adult ...

2016
Morshed Khandaker Shahram Riahinezhad Fariha Sultana Melville B Vaughan Joshua Knight Tracy L Morris

Implant failure due to poor integration of the implant with the surrounding biomaterial is a common problem in various orthopedic and orthodontic surgeries. Implant fixation mostly depends upon the implant surface topography. Micron to nanosize circular-shaped groove architecture with adequate surface roughness can enhance the mechanical interlock and osseointegration of an implant with the hos...

2017
Luting Liu Ritwik Bhatia Thomas J Webster

Titanium (Ti) and its alloys have been extensively used as implant materials in orthopedic applications. Nevertheless, implants may fail due to a lack of osseointegration and/or infection. The aim of this in vitro study was to endow an implant surface with favorable biological properties by the dual modification of surface chemistry and nanostructured topography. The application of a nanostruct...

2017
Markus Göttlicher Marcus Rohnke Yannik Moryson Jürgen Thomas Joachim Sann Anja Lode Matthias Schumacher Romy Schmidt Stefan Pilz Annett Gebert Thomas Gemming Jürgen Janek

BACKGROUND Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of special...

2012
Hiroyuki Tsuchiya Toshiharu Shirai Hideji Nishida Hideki Murakami Tamon Kabata Norio Yamamoto Koji Watanabe Junsuke Nakase

BACKGROUND Postoperative infection associated with implants remains a serious complication in orthopedic surgery. Several biomaterial surface treatments have been proposed as a means of reducing the incidence of implant-associated infections. In this study, a clinical trial was performed using an iodine-supported titanium that suppresses the microbial activities. METHODS A total of 222 patien...

Journal: :ACS applied materials & interfaces 2016
Peng Xiu Zhaojun Jia Jia Lv Chuan Yin Yan Cheng Ke Zhang Chunli Song Huijie Leng Yufeng Zheng Hong Cai Zhongjun Liu

3D printed porous titanium (Ti) holds enormous potential for load-bearing orthopedic applications. Although the 3D printing technique has good control over the macro-sturctures of porous Ti, the surface properties that affect tissue response are beyond its control, adding the need for tailored surface treatment to improve its osseointegration capacity. Here, the one step microarc oxidation (MAO...

Journal: :Journal of Functional Biomaterials 2023

Prolonged inflammation induced by orthopedic metallic implants can critically affect the success rates, which even lead to aseptic loosening and consequent implant failure. In case of adverse clinical conditions involving osteoporosis, trauma corrosion-wear in peri-implant region, reactive oxygen species (ROS) activity is enhanced leads increased oxidative stress. Metallic materials (such as ti...

Journal: :Materials Research-ibero-american Journal of Materials 2021

Porous titanium is proposed to be an effective orthopedic implant with a lower elastic modulus and supports osseointegration during implantation. To produce porous titanium, powder metallurgy (PM) assisted space-holder used in this study. Pure as the starting material, salt (NaCl) space-holder. Argon-atmospheric sintering arc plasma (APS) methods are applied for process. NaCl content was varied...

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