Das Projekt IKAR/OS (Intelligent Knowledge and Research Operating System) hat sich zum Ziel gesetzt, ein intelligentes Wissensmanagementsystem für die Lebenswissenschaften zu entwickeln. Das Projekt wird von der Firma iAS GmbH (CEO Dr. Hirsch) in Zusammenarbeit mit dem Humanwissenschaftlichen Zentrum der LMU München (Prof. Pöppel) und der Universität Bremen (Prof. Schill) durchgeführt.

OBJECTIVE To evaluate the respiratory and hemodynamic effects of open suctioning (OS) versus closed suctioning (CS) during pressure-control (PC) and volume-control (VC) ventilation, using a lung-protective ventilation strategy in an animal model of acute respiratory distress syndrome (ARDS). SETTING Animal laboratory in a university hospital. DESIGN Randomized cross-over evaluation. ANIMA...

Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of O...

PURPOSE To present a case of Weill-Marchesani syndrome with corneal endothelial dysfunction due to anterior dislocation of a spherophakic lens and corneolenticular contact. METHODS A 17-year-old woman presented with high myopia and progressive visual disturbance. She was of short stature and had brachydactyly. Her initial Snellen best corrected visual acuity (BCVA) was 20/50 (-sph 20.50 -cyl ...

Jim van Os has done us a service in bringing to attention the unsatisfactory nature of the concept of schizophrenia. He argues that the scientific evidence for the category is weak and that the present label is highly stigmatised. He suggests that a new concept – salience dysregulation syndrome – be assessed with regard to its clinical utility and patient acceptability. (Compare with Sato.) The...

Jim van Os has done us a service in bringing to attention the unsatisfactory nature of the concept of schizophrenia. He argues that the scientific evidence for the category is weak and that the present label is highly stigmatised. He suggests that a new concept – salience dysregulation syndrome – be assessed with regard to its clinical utility and patient acceptability. (Compare with Sato.) The...

BACKGROUND Although endotracheal suctioning induces alveolar derecruitment during mechanical ventilation, it is not clear whether repeated endotracheal suctioning exacerbates lung injuries. The present study aimed to determine whether repeated open endotracheal suctioning (OS) exacerbates lung injury compared to closed endotracheal suctioning (CS) during mechanical ventilation in an animal mode...

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