Tumor-associated macrophages (TAMs) are essential components of the immune cell stroma hepatocellular carcinoma. TAMs originate from monocytic myeloid-derived suppressor cells, peripheral blood monocytes, and kupffer cells. The recruitment monocytes to HCC tumor microenvironment is facilitated by various factors, leading their differentiation into with unique phenotypes. can directly activate o...

Introduction: Collagen I fibers that are visible with second harmonic generation (SHG) are associated with efficient tumor cell locomotion, and preferential locomotion along these fibers correlates with a more aggressively metastatic phenotype. Through mechanisms that are not yet well understood, macrophages are able to manipulate the structure of collagen fibers in the developing murine breast...

Tumor-associated macrophages (TAMs) originate in the circulation and are recruited to the tumor site by specific tumorderived attractants such as monocyte chemotactic protein-1 (1,2). By use of several mechanisms, TAMs bind to the tumor cells via glycoproteins, sugars, and phospholipids and become localized at the tumor–host tissue interface (2,3). Unlike macrophages that are involved in inflam...

Cancer invasion of the surrounding tissue is a multiscale process collective cell movement that involves not only tumour cells but also other immune in environment, such as tumour-associated macrophages (TAMs). The heterogeneity these cells, with two extremes being pro-inflammatory and anti-tumour M1 anti-inflammatory pro-tumour M2 has significant impact on cancer interact different ways ExtraC...

Inflammatory cells play important roles in progression of solid neoplasms including ovarian cancers. Tumor-associated macrophages (TAMs) contribute to angiogenesis and immune suppression by modulating microenvironment. Ovarian cancer develops occasionally on the bases of endometriosis, a chronic inflammatory disease. We have recently demonstrated differential expressions of CXCR3 variants in en...

BACKGROUND The ability of malignant tumors to metastasize presents a severe challenge in cancer treatment. Lymphatic vessels provide one of the main routes for tumor-metastasis on the way to regional lymph nodes. Increasing evidence suggests that inflammatory cells play an important role in tumor-associated angiogenesis and lymphangiogenesis. Recent data show that a specialized sub fraction of ...

BACKGROUND Treatment failure during highly active antiretroviral therapy (HAART) is ultimately common and associated with the development of resistance mutations. Trizivir (zidovudine/lamivudine/abacavir) and tenofovir disoproxil fumarate may improve adherence and enhance virological suppression in individuals who have failed previous regimens. METHODS Individuals were identified who had fail...

This study analyses the effects of vagotomy on tumor growth and survival in a murine, pancreatic cancer model in wild-type and TNFα-knockout (-/-) mice.Throughout many operative procedures in the upper gastrointestinal tract the partial or complete transection of the vagus nerve or its local nerve fibers is unavoidable. Thereby its anti-inflammatory effects in residual tumor tissue may get lost...

Purpose: The presence of tumor-associatedmacrophages (TAM) in breast cancer correlates strongly with poor outcome. The purpose of this study was to develop a clinically applicable, noninvasive diagnostic assay for selective targeting and visualization of TAMs in breast cancer, based on magnetic resonanceI and clinically applicable iron oxide nanoparticles. Experimental Design: F4/80-negativemam...

We show by immunohistochemical labeling that prominent cell types in the tumor microenvironment of PyMT transgenic mice are tumor-associated macrophages (TAMs) and endothelial cells, and that both populations are decreased in the presence of mitochondrial targeted catalase (mCAT). This observation suggests that mitochondrial ROS can drive tumor invasiveness in conjunction with the presence of T...