Research suggests that the quality of out-of-school time (OST) programs is related to positive youth outcomes and skilled staff are a critical component of high quality programming. This descriptive case study of competency frameworks for youth workers in the OST field demonstrates how experts and practitioners characterize a skilled youth worker. A comparative analysis of 11 competency framewo...

Introduction The National Energy Technology Laboratory (NETL) is the nation’s newest National Laboratory. It has campuses in Pittsburgh, PA, and Morgantown, WV. It is the premier DOE laboratory for fossil fuel research and has a history of more than 75-years of providing sciencebased, technological solutions to issues associated with the environmental, supply, and reliability constraints of pro...

BACKGROUND  Interferon-based hepatitis C virus (HCV) therapy is safe and effective among people receiving opioid substitution therapy (OST), but treatment uptake remains low. Our aim was to evaluate the impact of OST and drug use during therapy on completion, adherence, sustained virologic response (SVR12), and safety of ledipasvir/sofosbuvir ± ribavirin. METHODS  The phase 3 ION studies eval...

BACKGROUND Risk indices have been developed to identify women at risk of low bone mineral density (BMD) who should undergo BMD testing. AIM To compare the performance of four risk indices in White ambulatory women in Belgium. DESIGN Epidemiological cross-sectional study. METHODS Records were analysed for 4035 postmenopausal White women without Paget's disease or advanced osteoarthritis, s...

BACKGROUND The pandemic influenza A (H1N1) 2009 (H1N1pdm09) virus infection caused illness and death among people worldwide, particularly in hematologic/oncologic patients because influenza infected individuals can shed virus for prolonged periods, thus increasing the chances for the development of drug-resistant strains such as oseltamivir-resistant (OST-r) variant. METHODS The aim of our st...

BACKGROUND Several tests have been evaluated in horses for quantifying insulin dysregulation to support a diagnosis of equine metabolic syndrome. Comparing the performance of these tests in the same horses will provide clarification of their accuracy in the diagnosis of equine insulin dysregulation. OBJECTIVES The aim of this study was to evaluate the agreement between basal serum insulin con...

Heparan sulfate (HS) plays essential roles in assisting herpes simplex virus infection and other biological processes. The biosynthesis of HS includes numerous specialized sulfotransferases that generate a variety of sulfated saccharide sequences, conferring the selectivity of biological functions of HS. We report a structural study of human HS 3-O-sulfotransferase isoform 3 (3-OST-3), a key su...

The dolichol-linked oligosaccharide Glc3Man9GlcNAc2-PP-Dol is the in vivo donor substrate synthesized by most eukaryotes for asparagine-linked glycosylation. However, many protist organisms assemble dolichol-linked oligosaccharides that lack glucose residues. We have compared donor substrate utilization by the oligosaccharyltransferase (OST) from Trypanosoma cruzi, Entamoeba histolytica, Tricho...