Abstract Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression regulated by microRNA-223 (miR-223). Given that platelets are rich in miR-223, this study investigated the of SMOC1 and its contribution to platelet function. Human murine expressed SMOC1, whereas from SMOC1+/? mice did not present detectable mature protein. Platel...

Abstract Background Microcapsule is considered as a promising 3D microenvironment for Bone Tissue Engineering (BTE) applications. Microencapsulation of cells in an appropriate scaffold not only protected the against excess stress but also promoted cell proliferation and differentiation. Through current study, we aimed to microcapsulate human Dental Pulp Stem Cells (hDPSCs) evaluated osteogenic ...

Differential adhesion between migrating neurons and transient radial glial fibers enables the deployment of neurons into appropriate layers in the developing cerebral cortex. The identity of radial glial signals that regulate the termination of migration remains unclear. Here, we identified a radial glial surface antigen, SPARC (secreted protein acidic and rich in cysteine)-like 1, distributed ...

Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are widely used in a number of cell therapies and have osteogenic differentiation capacity. Exposure to electromagnetic fields (EMFs) increases the osteogenic differentiation of hBM-MSCs. Nanomagnetic particles (MPs) also promote the differentiation potential of stem cells. In the present study, we investigated the effects of EMFs and ...