Ovarian cancer is the most lethal gynecological malignancy, for which platinum- and taxane-based chemotherapy plays a major role. Chemoresistance of ovarian cancer poses a major obstacle to the successful management of this devastating disease; however, effective measures to overcome platinum and taxane resistance are yet to be established. In the present study, while investigating the mechanis...

ovarian borderline serous tumors are uncommon. combination of borderline serous adenofibromatous tumor and prominent micro papillary architecture is not previously reported. we report a case of borderline papillary serous adenofibromatous tumor (also called serous adenocarcinofibroma) with extensive micropapillary pattern in a 27 year-old married woman. she was infertile and presented with diff...

The development of cisplatin drug resistance remains a chief concern in ovarian cancer chemotherapy. β-Elemene is a natural plant product with broad-spectrum antitumor activity towards many types of carcinomas. This study aimed to define the biological and therapeutic significance of β-elemene in chemoresistant ovarian cancer. In the present study, β-elemene significantly inhibited cell growth ...

The Src protein tyrosine kinase is overexpressed and activated in a number of human cancers, including some human ovarian cancers. To determine whether Src activity plays a role in ovarian tumor growth, stable derivatives of the SKOv-3 human ovarian cancer cell line that exhibited reduced Src tyrosine kinase activity were generated by transfection with an antisense c-src construct. Comparison o...

Activation of the epidermal growth factor (EGF) receptor regulates many processes associated with metastasis, including modulation of cell:cell and cell:substrate interactions, production of matrix-degrading proteinases, and cellular migration. We have demonstrated previously that EGF stimulates migration and matrix metalloproteinase (MMP)-9-dependent invasion of ovarian cancer cells. In this s...

In this review, we will critically evaluate the evolution of the diagnostic tools used in the prediction of ovarian malignancy preoperatively, that has shown to get a better outcome for ovarian cancer patients. It will triage women to the best place for their surgery and by ensuring the expertise available to perform the surgery reducing the rate of incomplete primary surgery, that has reflecte...

The aim of the present study is to understand the hormonal mechanisms of the effect of malnutrition on ovarian follicle functions. For this purpose, we examined the effect of malnutrition/serum deprivation, addition of metabolic hormones and gonadotropin (IGF-I, leptin and FSH) and their combination on the release of progesterone (P4), testosterone (T), estradiol (E2) and insulin-like growth fa...

Present investigation was carried out to study the effect of stress on ovarian follicular activity in postpartum acyclic Sahiwal cows during hot-humid months. Postpartum monitored using trans-rectal ultrasound scanning alternate days beginning between day 60 and 90 (n=16) up next 21 days.Daily maximum temperature relative humidity recorded andtemperature-humidity index (THI)was calculated perio...

BACKGROUND Nuclear factor-kappa B (NF-kappaB) signaling is an important link between inflammation and peritoneal carcinomatosis in human ovarian cancer. Our objective was to track NF-kappaB signaling during ovarian cancer progression in a syngeneic mouse model using tumor cells stably expressing an NF-kappaB reporter. METHODS ID8 mouse ovarian cancer cells stably expressing an NF-kappaB-depen...

A series of 16 benign human ovarian neoplasms of either stromal or epithelial origin, with one exception, showed transfer RNA methylase specific activity and tRNA-methylating capacity comparable to that of normal ovarian tissue and not to malignant ovarian tumor tissue. The exception was an arrhenoblastoma, a rare masculinizing type of tumor which, although classified as benign, is known to hav...