21 Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late 22 stage, with a 5-year survival rate of less than 30%. The majority of ovarian cancer cases are 23 diagnosed after tumors have widely spread within the peritoneal cavity, limiting the effectiveness 24 of debulking surgery and chemotherapy. Owing to a substantially lower survival rate at late 25 sta...

Ovarian cancer represents the fourth most frequent type of cancer among females and is the leading cause of death from gynecological cancer in the western world. This review describes gene alterations in ovarian cancer. Specific emphasis is placed on genetic alterations and the prevalence of TP53 (p53) gene alterations in the distinct biological ovarian tumors (benign, borderline, and malignant...

background : the brain is a rare site of metastases from ovarian cancer. limited data are available on prognostic factors, standard treatment, and survival. knowledge of clinical prognostic factors would help the management of patients with brain metastases. the aim of this study is to evaluate the impact of clinical factors and treatment modalities on survival in patients with brain metastases...

from december 2000 until 2010, the researchers at royan institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. in 2010, royan institute established the royan human ovarian tissue bank as a subgroup of the embryology department. since its i...

Ovarian cancer is the fifth leading cause of cancer deaths among women and the most common type of gynecologic malignancy. Despite advances in surgery and chemotherapy, the survival rate of patients with epithelial ovarian cancer is still low. For a whole decade, that situation has not improved. Most ovarian cancer patients relapse and become drug-resistant. Increasing evidence has suggested th...

BACKGROUND Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on ovarian cancer cell lines (A2780 cells and its chemoresistant derivative A2780/ADR, SKOV3 and HEY...

We investigated the possibility that chemokine gradients influence migration of human ovarian epithelial tumor cells. Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells. CXCR4 mRNA localized to a subpopulation of tumor cells in ovarian cancer biopsies. Ovarian cancer cell lines and cells freshly isolated from ascites expressed CXCR4 protein. The CXCR4 ligan...

We investigated the possibility that chemokine gradients influence migration of human ovarian epithelial tumor cells. Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells. CXCR4 mRNA localized to a subpopulation of tumor cells in ovarian cancer biopsies. Ovarian cancer cell lines and cells freshly isolated from ascites expressed CXCR4 protein. The CXCR4 ligan...

To investigate the association between endometriosis, tubal ligation, hysterectomy and epithelial ovarian cancer. Relevant published literatures were searched in PubMed, ProQuest, Web of Science and Medline databases during 1995-2016. Heterogeneity was evaluated by I² statistic. Publication bias was tested by funnel plot and Egger's test. Odds ratio and 95% CI were used to assess the associatio...

Inherited mutations in BRCA1 and BRCA2 lead to significantly increased risks of breast and ovarian cancer. We used epidemiologic methods to evaluate the relative risks of breast cancer vs. ovarian cancer among women of Ashkenazi Jewish ancestry with inherited mutations in BRCA1 or BRCA2. The cancer of a family's index case (i.e., breast cancer vs. ovarian cancer) was significantly associated wi...