Kisspeptins, the products of the KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54), have recently emerged as pivotal signals in the hypothalamic network triggering the preovulatory surge of gonadotropins and, hence, ovulation. Additional actions of kisspeptins at other levels of the hypothalamic-pituitary-ovarian axis have been suggested but remain to date scarcely studied. We report...

Peritoneal pseudocysts (PPCs) are generally not well recognized and often present a diagnostic dilemma to clinicians and radiologists alike. These benign entities typically arise in females of reproductive age on a background of pelvic adhesions and peritoneal dysfunction where ovarian fluid is retained within loculated cystic collections. This review will illustrate the broad spectrum of appea...

l p g ( N a Polycystic ovarian syndrome (PCOS) is considered the most common endocrine disorder among women of reproductive age, but prevalence estimates have varied from a low of 4.6% found by Knochenhauer et al in 1998 to a high of .8% noted by Diamanti-Kandarakis et l in 1999. Other estimates have fallen etween these ranges. The exact cause of PCOS still is unknown, but it is characterized b...

Polycystic ovary syndrome is a common endocrinopathy characterized by oligo ovulation or anovulation, signs of androgen excess and multiple small ovarian cysts. It includes various metabolic abnormalities: insulin resistance, hyperinsulinemia, impaired glucose tolerance, visceral obesity, inflammation and endothelial dysfunction, hypertension and dyslipidemia. All these metabolic abnormalities ...

Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD often precedes the cancer diagnosis by months to years. Here, we report the case of a 64-year-old woman who developed PCD symptoms, associated with high levels of anti-Yo antibodies, one year after a previo...

BACKGROUND The success of intrauterine insemination with donor semen (IUI-DI) is likely to be influenced by a number of variables, including age and ovarian stimulation (OS) regime. METHODS AND RESULTS A retrospective analysis of 1056 treatment cycles in 261 women (212 single heterosexuals and 49 lesbians) was conducted to assess the influence of these two variables on pregnancy outcome durin...

Turner syndrome (TS), a chronic childhood disease, requires growth hormone (GH) treatment for short stature in pediatrics and sex hormone replacement therapy (HRT) in the adult health-care setting with transition during adolescence managed by gynecologists or endocrinologists (1). However, many women with TS are reported to be receiving inadequate health care. Only 24 of 39 (63%) TS patients re...