Ovarian cancer accounts for only 3% of all cancers in women, but it causes more deaths than any other gynecologic cancer. Treatment with chemotherapy and cytoreductive surgery shows a good response to the therapy. However, in a large proportion of the patients the tumor grows back within a few years. Cancer stem cells, that are less responsive to these treatments, are blamed for this recurrence...

Whether classifi ed as “tumor-initiating” cells, “cancer stem-like” cells or simply “cancer stem cells” (CSCs), this small population of highly undiff erentiated and slow cycling cells is implicated in early molecular events linked to cancer development as well as in tumor progression, recurrence, and development of chemotherapy resistance (1). During the last decade an increasing amount of sci...

Primary ovarian cancer is responsive to treatment, but chemoresistant recurrent disease ensues in majority of patients. Recent compelling evidence demonstrates that a specific population of cancer cells, the cancer stem cells, initiates and sustains tumors. It is therefore possible that this cell population is also responsible for recurrence. We have shown previously that CD44+/MyD88+ epithelia...

introduction: stem cell biology has been the subject of much recent discussion. embryonic stem (es) cells, derived from the inner cell mass of the blastocyst stage of early mammalian embryos are expected to become a powerful tool in future regenerative medicine and developmental biology due to their capacity of self-renewal and pluripotency. in the present study, the ultrastructural development...

introduction: nowadays, spermatogonial stem cells (sscs) cultivation has been used by many researchers as an effective tool for infertility treatments. oxidative conditions can be effective on cell proliferation and differentiation of these cells. so, the aim of this study was to establish oxidative stress model for antioxidant activity of some drugs investigation during sscs in vitro culture. ...

bachgroun: hematopoietic stem cell derived from umbilical cord blood (ucb) has been used for regenerative medicine in hematological abnormalities. micrornas are important regulators of gene expression that control both physiological and pathological processes such as development of tissue and cancer. some studies have shown that mir-33, has a critical role in control of self-renewal cells. here...

background: mesenchymal stem cells (mscs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. however, the low survival rate of these cells restricts their therapeutic applications. it is hypothesized that autophagy might play an important role in cellular homeostasis and survival. this study aims to investigate the regenerative potentia...

background: retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hucm). methods: after isolation, hucm were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. also, doubling time of the cells and their differentiation potential into adipoge...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

there are two main methods for preparing the puramatrix (pm) as a three-dimensional (3-d) scaffold for supporting the cells including surface plating and encapsulation. in the surface-plating procedure, the scaffold is created by adding an ionic agent such as medium to pm. after adjusting the ph by changing the medium, cells are seeded on top of the scaffold. in the encapsulation method, pm and...