Abstract Group 4 medulloblastoma (MB) is the most common subgroup and shows high incidence of metastasis late-onset relapse cases. These tumors lack a unifying oncogenic driver treatment targets, despite extensive genomic characterization. MBs are characterized by recurrent genetic alterations in chromatin modifiers amplification stemness genes. A substantial fraction enhancer hijacking through...

Abstract Background The CIPKs are a group of plant-specific Ser/Thr protein kinases acting in response to calcium signaling, which plays an important role the physiological and developmental adaptation plants adverse environments. However, functions halophyte-derived CIPK s still poorly understood, that limits potential application from halophytes for improving tolerance glycophytes abiotic str...

Abstract Group 4 medulloblastoma (MB) is the most common subgroup and shows high incidence of metastasis late-onset relapse. MBs lack a unifying oncogenic driver treatment targets, despite extensive genomic characterization. are characterized by recurrent genetic alterations in chromatin modifiers, amplification stemness genes, putative enhancer "hijacking" events. A substantial fraction hijack...