The adsorption of the fluorescent dye, Oxazine 1 (OX) was studied on graphene oxide (GO), in range low (⩽10−7 M) OX concentrations, exploiting high sensitivity fluorescence spectroscopy. Dry GO characterized using XRD, TEM, XPS, Raman and IR spectroscopy, while its chemistry aqueous suspension examined with potentiometric titration. Adsorption isotherms were measured at pH 6.4 10.2 temperatures...

A series of benzoxazine monomer supramolecules with different substituted groups on their benzene ring was prepared with a Mannich reaction and characterized by FTIR, 1H-NMR and MS. The obtained products were 3,4-dihydro-3-(2'-hydroxyethylene)-6-methyl-2H-benzoxazine (BM1), 3,4-dihydro-3-(2'-hydroxyethylene)-6-ethyl-2H-benz-oxazine (BM2), and 3,4-dihydro-3-(2'-hydroxyethylene)-6-methoxy-2H-benz...

Metallic nanostructures were prepared through the alternate immersion of derivatized glass slides in solutions of gold nanoparticles (NPs) and a propanedithiol linker molecule. Nanostructures consisting of 1-17 depositions of gold NPs were synthesized, and these substrates were characterized using UV-vis spectroscopy and atomic force microscopy. Subsequently, the surface-enhanced Raman scatteri...

Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1) [(•})ofloxacin; DL-8280; (•} )-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl1 -piperazinyl)-7-oxo-7Hpyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid] and their fluoromethyl derivatives (14a and 14b) were prepared via their optically active intermediates resolved by use of high-performance liquid chromatography...

Cytochrome P450 2B6 (CYP2B6) is primarily responsible for the metabolism of the anti-HIV drug efavirenz (EFV). We set out to explore the molecular basis for CYP2B6 activity toward EFV by examining the metabolism of eight EFV analogues. cDNA-expressed CYP2B6 formed monooxygenated metabolites from EFV analogues containing an intact oxazinone or oxazine ring, but not from analogues with a disrupte...

The structure and energetic properties of four common oxazine dyes, Nile red, Nile blue A, Cresyl violet, and Brilliant cresyl blue, have been probed using a combination of infrared multiple-photon dissociation (IRMPD) spectroscopy and quantum chemical calculations. IRMPD spectra of the protonated dyes, as generated from an electrospray ionization (ESI) source, were collected in the range of 90...

PA-824 is a novel nitroimidazo-oxazine being developed as an antituberculosis agent. Two randomized studies evaluated the pharmacokinetics and safety of a single oral dose of PA-824 administered to healthy adult subjects 30 min after a high-calorie, high-fat meal (fed state) versus after a minimum 10-h fast (fasted state). A total of 48 subjects were dosed in the two studies in a randomized cro...