Oxidative stress is involved in chronic and acute pathologies: cardiovascular, neurodegenerative, neoplastic, inflammatory and infectious diseases. Clinical trials focused on prevention of cardiovascular and neoplastic diseases involving antioxidant supplementation have however provided predominantly negative obserations in large-scale studies. Screening of patient cohorts to assess baseline ox...

the aim of this study is to investigate antioxidant enzymes, oxidative stress biomarkers and the acute phase proteins levels for subclinical and clinical pregnancy toxemia and to determine the effect of early diagnosis on the success of curing. according to the results of clinical and biochemical parameters, from 39 ewes, 10 were healthy ewes (control group), 13 ewes had subclinical pregnancy t...

Objective: Inflammation along with oxidative stress plays an important role in the development, progression, instability and rupture of coronary atherosclerotic plaques. Several studies introduced curcumin (diferuloylmethane) as a wonderful chemical in Curcuma longa<span style="font-size: m...

The objectives of the present study were to evaluate the effect of normobaric and hyperbaric O2 (HBO) on plasma antioxidants and biomarkers of oxidative stress in plasma and urine and to investigate the effect of a 4-week vitamin C plus E supplementation on HBO-induced oxidative stress. Nineteen healthy men were exposed to HBO (100 % O2; 240 kPa) before and after 4 weeks' supplementation with 5...

BACKGROUND Volatile organic compounds (VOCs) in breath may contain biomarkers of active pulmonary tuberculosis derived from the infectious organism (metabolites of Mycobacterium tuberculosis) and from the infected host (products of oxidative stress). METHODS We analyzed breath VOCs in 226 symptomatic high-risk patients in USA, Philippines, and UK, using gas chromatography/mass spectroscopy. D...

Cigarette smokers experience an exaggerated triglyceride (TAG) and oxidative stress response to high fat feeding. Exercise training may serve to attenuate the rise in these variables, by improving TAG clearance and antioxidant defense. We compared blood TAG, antioxidant capacity, and oxidative stress biomarkers in exercise trained (>2 hrs per wk) and untrained smokers matched for age, in respon...

BACKGROUND Abdominal adiposity has been linked to metabolic abnormalities, including dyslipidemia, oxidative stress, and low-grade inflammation. OBJECTIVE To test the hypothesis that consumption of 100% orange juice (OJ) would improve metabolic, oxidative, and inflammatory biomarkers and cytokine levels in normal and overweight subjects with increased waist circumference. DESIGN Subjects we...

Metabolomics is the systematic study of metabolites as small-molecule biomarkers that represent the functional phenotype in a cell, tissue or organism. Detection of crucial disturbances in the concentration of metabolites by metabolomic profiling of key biomarkers can be beneficial in the management of various medical conditions, including male-factor infertility. Recent studies have demonstrat...

The aim of this study is to evaluate the status of endogenous antioxidant defense system in H. pylori-infected endoscopically diagnosed chronic duodenal ulcer patients through the assessment of certain oxidative stress biomarkers. These biomarkers namely plasma malodialdehyde (MDA) and blood activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) are to be evaluated before and...

background: the early stage of copper poisoning is difficult to be clinically diagnosed in sheep and has not been documented clearly yet. objectives: to assess biomarkers in predicting early copper poisoning in sheep, blood samples were collected from several groups of animals from a naturally copper poisoning occurrence in an industrial region. methods: animals were divided into four experimen...