نتایج جستجو برای: oxidative deamination
تعداد نتایج: 129895 فیلتر نتایج به سال:
It has been demonstrated that biotin is concerned with the enzymatic decarboxylation of oxalacetate (l-4), the reversible deamination of aspartate (5, S), and the deamination of serine and threonine (5,6). By analogy with other vitamins it might be suspected that biotin does not function in these reactions as such, but is converted into a coenzyme form. The evidence outlined below suggests that...
DNA demethylation in mammalia occurs after fertilization and during embryogenesis and accompanies cell aging and cancer transformation. With the help of the primer extension reaction, MALDI MS and DNA cleavage by thymine DNA glycosylase deamination of 5-methylcytosine residues has been shown to take place when the model methylated DNA duplexes are treated with nuclear extracts from the cell lin...
It has been demonstrated that biotin is concerned with the enzymatic decarboxylation of oxalacetate (l-4), the reversible deamination of aspartate (5, S), and the deamination of serine and threonine (5,6). By analogy with other vitamins it might be suspected that biotin does not function in these reactions as such, but is converted into a coenzyme form. The evidence outlined below suggests that...
The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity factor Vif. Inhibition of HIV replication occurs by both deamination of viral single-stranded DNA and a deamination-independe...
A discussion of nitrosative deamination of cytosine 1 is presented that argues for the formation of 6 by diazotization of 1 to cytosinediazonium ion 2 and its electrostatic complex 3, dediazoniation to 4 <--> 5, and amide-bond cleavage to 6. The reaction channels available to 6 include hydrolytic deglycation to 3-isocyanatoacrylonitrile 7, water addition to carbamic acid 9 with the possibility ...
The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are incompletely understood. Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. This editing alters the amino acid sequences for scores of proteins, including many that are involved ...
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