Endothelial apoptosis is a driving force in atherosclerosis development. Oxidized LDL promotes inflammatory and thrombotic processes and is highly atherogenic, as it stimulates macrophage cholesterol accumulation and foam cell formation. This study investigated multiple mitogen-activated protein kinase (MAPK)-responsive death/survival signaling pathways, through which flavonoids of (-)epigalloc...

Background: Atherosclerosis is an inflammatory and multifactorial disease, with a high prevalence rate in Pakistan. Objective: To find a relation between serum IL-4 and IgE levels with oxidized LDL in atherosclerosis. Methods: In this observational, cross sectional study 99 male patients, between forty and sixty years of age, with a history of ischemic heart disease (IHD) and established athero...

Due to the high hardness and wear resistance, electroless nickel-boron (Ni-B) coatings have found numerous applications. In the present study, the influence of the heating rate on the morphological features of oxidized electroless Ni-B coatings was investigated. The oxidation behavior of electroless coating layers was studied with TGA method under non-isothermal conditions at heating rates 5, 9...

Background: Super oxidized water (SOW), as a novel antiseptic solution, is used with claims of effectiveness and cost effectiveness in healing chronic wounds such as diabetic foot, infectious post-operative ulcers and burn ulcers. We conducted a health technology assessment to evaluate the clinical evidence from clinical and randomized trials for this disinfection. This study aims to evaluate t...

Oxidizing conditions have not been explored well for the in vitro random mutagenesis in directed evolution. The mutagenic potential of diverse range of oxidized products is well reported in literature. Incorporation of errors during PCR in the presence of oxidized nucleotides can be a very effective alternative to error prone PCR as the transversion mutation frequency is higher in the former ca...

We examined whether oxidized lipids in the diet determine the levels of oxidized lipid in human postprandial serum chylomicrons. After we fed subjects control corn oil containing low quantities of oxidized lipid, the levels of conjugated dienes in the chylomicron fraction were low (9.67 +/- 0.92 nmol/mumol triglyceride), and no thiobarbituric acid-reactive substances (TBARS) could be detected. ...

Cardiolipin (CL) is a dimeric phospholipid with critical roles in mitochondrial bioenergetics and signaling. Recently, inhibition of the release of oxidized fatty acyl chains from CL by the calcium-independent phospholipase A2γ (iPLA2γ)-selective inhibitor (R)-BEL suggested that iPLA2γ is responsible for the hydrolysis of oxidized CL and subsequent signaling mediated by the released oxidized fa...

Copyright © Korean Carbon Society http://carbonlett.org Abstract The use of carbon nanotubes (CNTs) as a reinforcing material in a polymer matrix has increased in various industries. In this study, the flexural behavior of CNT-modified epoxy/ basalt (CNT/epoxy/basalt) composites is investigated. The effects of CNT modification with silane on the flexural properties of CNT/epoxy/basalt composite...

Oxidized low-density lipoprotein (LDL) is proatherogenic and induces smooth muscle cell apoptosis, which contributes to atherosclerotic plaque destabilization. We showed previously that oxidized LDL downregulates insulin-like growth factor-1 receptor in human smooth muscle cells and that this is critical for induction of apoptosis. To identify mechanisms, we exposed smooth muscle cells to 60 mu...