Inhalation of high concentration of oxygen produces oxidative stress in men and experimental animals. Our previous experiments showed that the cough reflex is suppressed in guinea pigs after exposure to 100% O(2) for 60 hours. The aim of this study was to determine the effects of dietary antioxidant supplementation with vitamins C and E on hyperoxia-induced oxidative stress in airway and lung t...

Authors’ address: Howard S. Gruber and Marshall H. Klaus, Case Western Reserve School of Medicine, Department of Pediatrics, Cleveland, O. (USA) Thirty-six infants (mean birthweight 1709 g) with severe HMD were treated with intermittent mask and bag ventilation as an alternative to the mechanical respirator. Previous therapy with oxygen, NaHCO7⁄8, glucose infusion and thermoregulation was judge...

Inhalation anesthesia with isoflurane is a well-established and safe method used in small laboratory animals. In most cases oxygen is used as a carrier gas for isoflurane, but room air or mixtures of oxygen with air or nitrous oxide are also being used. Anesthesia is therefore administered using different fractions of inspired oxygen (FiO2), and this may have consequences for the outcome of exp...

Bronchopulmonary dysplasia is a lung disease that the most common complication of prematurity and chronic in neonates treated with mechanical ventilation and/or oxygen therapy. Children bronchopulmonary are at risk cardiovascular complications, such as pulmonary arterial hypertension left ventricular hypertrophy. The presented case concerns premature infant born 24 weeks gestation severe compli...

OBJECTIVES The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. DESIGN In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% o...