Brain-computer interfaces (BCIs) are now feasible for use as an alternative control option for those with severe motor impairments. The P300 component of the evoked potential has proven useful as a control signal. Individuals do not need to be trained to produce the signal, and it is fairly stable and has a large evoked potential. Even with recent signal classification advances, on-line experim...

In this paper, we evaluate the control performance of SSVEP (steady-state visual evoked potential)- and P300-based models using Cerebot-a mind-controlled humanoid robot platform. Seven subjects with diverse experience participated in experiments concerning the open-loop and closed-loop control of a humanoid robot via brain signals. The visual stimuli of both the SSVEP- and P300- based models we...

OBJECTIVE To characterize downstream effectors of p300 acetyltransferase in the myocardium. BACKGROUND Acetyltransferase p300 is a central driver of the hypertrophic response to increased workload, but its biological targets and downstream effectors are incompletely known. METHODS AND RESULTS Mice expressing a myocyte-restricted transgene encoding acetyltransferase p300, previously shown to...

Background: The P300 components of auditory event related potentials (ERPs) are objective measures related to information and cognitive processing. Objectives: To assess P300 ERPs in female patients with fibromyalgia (FM) in comparison with healthy age matched controls. To investigate the relationship between P300 potentials and pain threshold levels of patients, and subsequent effect of sertra...

Acetylation of proteins by p300 histone acetyltransferase plays a critical role in the regulation of gene expression. The prior discovery of an autoacetylated regulatory loop in the p300 histone acetyltransferase (HAT) domain prompted us to further explore the mechanisms of p300 autoacetylation. Here we have described a kinetic and mass spectrometric analysis of p300 HAT autoacetylation. The ra...

BACKGROUND The P300 components of auditory event related potentials (ERPs) are objective measures related to information and cognitive processing. OBJECTIVES To assess P300 ERPs in female patients with fibromyalgia (FM) in comparison with healthy age matched controls. To investigate the relationship between P300 potentials and pain threshold levels of patients, and subsequent effect of sertra...

BACKGROUND Cardiovascular malformations can be caused by abnormalities in Gata4 expression during fetal development. In a previous study, we demonstrated that ethanol exposure could lead to histone hyperacetylation and Gata4 over-expression in fetal mouse hearts. However, the potential mechanisms of histone hyperacetylation and Gata4 over-expression induced by ethanol remain unclear. METHODS ...

The possibility that the P300 component of the event-related potential (ERP) may have etiological significance for alcoholism has been discussed for over a decade now (Pfefferbaum et al 1979; Hill et al 1986). A number of cross-sectional studies (Begleiter et al 1984; Hill et al 1990; Whipple et al 1991) have demonstrated decrements in the amplitude of P300 in high-risk children. Only one study...

In this study, we examined the effects of a short mindfulness meditation induction (MMI) on the performance of a P300-based brain–computer interface (BCI) task. We expected that MMI would harness present moment attentional resources, resulting in two positive consequences for P300-based BCI use. Specifically, we believed MMI would facilitate increases in task accuracy and promote the production...

BACKGROUND Prior research has shown reductions of the N1, N2, and P300 auditory event-related potential (ERP) components in schizophrenic patients. Most studies have shown a greater P300 reduction in left versus right temporal leads in schizophrenic patients. These studies were done with sparse electrode arrays, covering restricted areas of the head, thus providing an incomplete representation ...