نتایج جستجو برای: p46
تعداد نتایج: 204 فیلتر نتایج به سال:
39 40 Small intestinal ulceration, bleeding, and inflammation are major adverse effects 41 associated with the use of diclofenac (DCF) or other nonsteroidal anti-inflammatory 42 drugs (NSAIDs). The underlying mechanisms of DCF enteropathy are poorly understood, 43 but there is increasing evidence that topical effects are involved. The aim of this study 44 was to explore the role of c-Jun-N-term...
High-fat (HFD) and high-sucrose diets (HSD) reduce insulin suppression of glucose production in vivo, increase the capacity for gluconeogenesis in vitro, and increase glucose-6-phosphatase (G-6-Pase) activity in whole cell homogenates. The present study examined the effects of HSD and HFD on in vivo gluconeogenesis, the catalytic and glucose-6-phosphate translocase subunits of G-6-Pase, glucoki...
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, and debilitating fatigue. Dysregulation of type I interferon (IFN) pathway is a prominent feature of SS and is correlated with increased autoantibody titers a...
To study the mechanisms by which catecholamines regulate hepatocyte proliferation after partial hepatectomy (PHX), hepatocytes were isolated from adult male rats 24 h after sham operation or two-thirds PHX and treated with catecholamines and other agonists. In freshly isolated sham cells, p42 mitogen-activated protein (MAP) kinase activity was stimulated by the alpha1-adrenergic agonist phenyle...
The endogenous nucleoside adenosine is thought to play a role in the pathophysiology of asthma by stimulating mast cells. We previously showed that the human mast cell line HMC-1 expresses A2A and A2B receptors, and that both receptors activate adenylate cyclase via Gs-protein but that only A2B receptors are also coupled to phospholipase C via Gq proteins. Stimulation of A2B but not A2A recepto...
Let K (k) n be the complete k-uniform hypergraph, k ≥ 3, and let ` be an integer such that 1 ≤ ` ≤ k − 1 and k − ` divides n. An `-overlapping Hamilton cycle in K (k) n is a spanning subhypergraph C of K (k) n with n/(k− `) edges and such that for some cyclic ordering of the vertices each edge of C consists of k consecutive vertices and every pair of adjacent edges in C intersects in precisely ...
Small intestinal ulceration, bleeding, and inflammation are major adverse effects associated with the use of diclofenac (DCF) or other nonsteroidal anti-inflammatory drugs (NSAIDs). The underlying mechanisms of DCF enteropathy are poorly understood, but there is increasing evidence that topical effects are involved. The aim of this study was to explore the role of c-Jun-N-terminal kinase (JNK) ...
Aims With an MRI scanner at the limit of capacity (and no immediate prospect of an additional scanner) we are unable to offer pre biopsy MRI due to the workload expansion-further 24 slots/ month. We aimed to evaluate if reducing the time between biopsy and scan led to a decrease in staging accuracy due to post biopsy haemorrhage. Methods Retrospective study comparing haemorrhagic artefact and s...
The effects of interleukin 1 (IL-1) are mediated by the activation of protein kinase signalling pathways, which have been well characterized in cultured cells. We have investigated the activation of these pathways in rabbit liver and other tissues after the systemic administration of IL-1alpha. In liver there was 30-40-fold activation of c-Jun N-terminal kinase (JNK) and 5-fold activation of bo...
Macrophages are a main component of atherosclerotic plaques. Recent studies suggest that pro-inflammatory M1 macrophages are pro-atherogenic while M2 macrophages promote plaque stability. Moreover, toll-like receptor signalling pathways are implicated in atherosclerotic plaque formation, evolution and regression. We propose microRNAs as key regulators of these processes. In this context, our go...
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