Pain is a common and distressing symptom in ICU patients. Yet a major challenge exists in assessing and evaluating the pain. Although the patient's self-report of pain is the "gold standard" for pain assessment, other methods must be considered when patients are unable to self-report. Currently only two pain behavior instruments have been tested for their reliability, validity, and feasibility ...

  In the present study, the effect of contralateral and bilateral electrolytic lesions of the nucleus reticularis paragigantocellularis (PGi) on tonic pain was assessed in rats. Pain-related behavior was evaluated using the formalin test 7 days after the lesion was made. PGi lesions did not produce any marked changes in the early phase of the formalin test, but significantly increased pain sens...

background low back pain (lbp) is the most common and multifactor problem among the commercial drivers and the individual, social, psychological and occupational factors have important role in intensifying this pain. in various studies, the role of spiritual factor was investigated less compared to other factors. objectives the aim of this study was to investigate the effect of religious belief...

As living condition has been shown to affect rates of neurogenesis, the current study was designed to examine the relationship between neurogenesis and pain behavior, particularly stressinduced analgesia (SIA) and tonic pain. Mice received daily injection stress and were placed in group or isolated housing conditions, with or without access to a running wheel in order to differentially manipula...

Pain behavior observation is recommended for pain assessment in the elderly with dementia. may be useful not only patients dementia but also those cognitive impairment general. However, characteristics of differ depending on degree decline. This study examined using verbal rating scale (VRS) and Abbey (APS) adults mild (MCI)

background and aims. dental practitioners have numerous methods to control anxiety and pain in children, and distracting the child appears to be the most common technique used for behavior management during dental procedures. the aim of the present study was to evaluate the influence of using virtual reality eyeglasses on severity of pain and anxiety during dental procedures in pediatric patien...

BACKGROUND Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC) is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent inflammation, but IC symptoms correlate with elevated bladder lamina propria mast cell counts. We hypothesized that mast cells mediate pelvic pai...

Pain per se may increase anxiety and conversely, anxiety may increase pain. Therefore, a positive feedback loop between anxiety and pain possibly contributes to pain and suffering in some pathophysiological pain conditions, such as that induced by peripheral nerve injury. Recent results indicate that transient receptor channels 4 and 5 (TRPC4/C5) in the amygdala have anxiogenic effects in roden...

Corticotropin-releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression. The amygdala plays an important role in affective states and disorders such as anxiety and depression. The amygdala is also emerging as a neural substrate of pain affect. However, the involvement of the amygdala in the interaction of pain and anxiety remains to be determ...

Establishment and validation of ethologically-relevant, non-evoked behavioral end-points as surrogate measures of spontaneous pain in rodent pain models has been proposed as a means to improve preclinical to clinical research translation in the pain field. Here, we compared the utility of burrowing behavior with hypersensitivity to applied mechanical stimuli for pain assessment in rat models of...