Three-strand oligonucleotide complexes are employed to assess the effect of base stacking and base pair mismatch on the relative thermodynamic stabilities of oligonucleotide duplexes. The melting behavior of three-strand oligonucleotide complexes incorporating nicks and gaps as well as internal single base mismatches is monitored using temperature-dependent optical absorption spectroscopy. A se...

Ion-pairing is reported to improve the lipophilicity and subsequently the transport rate of polar drugs across lipid membranes. Lipophilisation of ionic drugs with high aqueous solubilities by ion-pair formation with appropriate counter-ion have proven to be promising for several applications. The aim of this review is to present the usefulness of ion-pair for improving the poor bioavailability...

It is a standard exercise in mechanical engineering to infer the external forces and torques on a body from a given static shape and known elastic properties. Here we apply this kind of analysis to distorted double-helical DNA in complexes with proteins: We extract the local mean forces and torques acting on each base pair of bound DNA from high-resolution complex structures. Our analysis relie...

let g be a (p,q) graph. an injective map f : e(g) → {±1,±2,...,±q} is said to be an edge pair sum labeling if the induced vertex function f*: v (g) → z - {0} defi ned by f*(v) = σp∈ev f (e) is one-one where ev denotes the set of edges in g that are incident with a vertex v and f*(v (g)) is either of the form {±k1,±k2,...,±kp/2} or {±k1,±k2,...,±k(p-1)/2} u {±k(p+1)/2} according a...

We present a thorough study of the theoretical properties and devise efficient algorithms for persistent Laplacian, an extension standard combinatorial Laplacian to setting pairs (or, in more generality, sequences) simplicial complexes $K \hookrightarrow L$, which was recently introduced by Wang, Nguyen, Wei. In particular, analogy with nonpersistent case, we first prove that nullity $q$th $\De...

The article is focused on the study of geometric petroglyphs Southern Siberia and Mongolia. All them are characterized by presence anthropomorphic features. were divided into three complexes. first complex a parabola with recess at top pair “legs” bottom. second one combination rectangles trapezoids “legs”. Sometimes they have “heads”, “hands” “vulvas”. third poles crossbars, which rectangular ...

the vo(iv) complexes of tridentate ono schiff base ligands derived from 2- aminobenzoicacid and salicylaldehyde derivatives were synthesized and characterized by ir, uv–vis and elemental analysis. electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. a good linear correlation was observed between the oxidation potentials and the electron-withdrawing charac...