Chloroquine is the drug very frequently used for the treatment of malaria. It is also used in amebiasis, rheumatoid arthritis, and various dermatological conditions. Chloroquine can cause muscle problems, loss of appetite, and diarrhea as a side effect. Cutaneous toxicity includes pruritus, hair loss, photosensitivity, and color changes. Exfoliation of skin over palms and soles is caused by che...

A 51-year-old man reported with progressive thickening of the skin of the hands and feet since the age of 6yrs. It was largely asymptoma c; however, brisk walking caused excessive swea ng, pain, and widening of the fissures on the soles of the feet. He also had scaly raised lesions on legs and knees. His mother, maternal aunt, cousin and nephew had similar lesions. Examination of the soles of f...

A 9-year old boy had severe muscle weakness and typical skin rash and EMG with diagnosis of dermatomyositis associated with erythrodermia with islands of normal skin and palmoplantar hyperkeratosis, which was reported. As PRP in skin biopsy. Association dermatomyositis with PRP is very rare.

Punctate palmoplantar keratoderma (PPPK) is a rare entity with an estimated prevalence rate of 1.17/100,000. PPPK usually presents with bilateral asymptomatic, tiny, hyperkeratotic punctate papules and plaques on the palmoplantar surface. Among the PPPK varieties, the linear presentation is much rarer, and so far there have been only 3 case reports. Here, we report the case of a 27-year-old fem...

836 © 2007 The Authors JEADV 2007, 21, 822–849 Journal compilation © 2007 European Academy of Dermatology and Venereology 5 Hesse S, Berbis P, Privat Y. Keratoderma palmoplantaris papulosa (Bushcke–Fischer’s disease): efficacy of acitretin. Br J Dermatol 1993; 128: 104–105. 6 Horikoshi M, Kuroda K, Tajima S. Puncate palmoplantar keratoderma with pigmentary lesions on the dorsa of feet and ankle...