OBJECTIVE To investigate the impact white matter hyperintensities (WMH) detected on magnetic resonance imaging have on motor dysfunction and cognitive impairment in elderly subjects without dementia. DESIGN Cross-sectional study. SETTING Population-based study on the incidence and prevalence of cognitive impairment in Olmsted County, Minnesota. PARTICIPANTS A total of 148 elderly subjects...

Human research has shown that lesions of the parietal cortex disrupt spatial information processing, specifically topological information. Similar findings have been found in non-humans. It has been difficult to determine homologies between human and non-human mnemonic mechanisms for spatial information processing because methodologies and neuropathology differ. The first objective of the prese...

It has been argued that we map observed actions onto our own motor system. Here we added to this issue by investigating whether hand preference influences the neural correlates of action observation of simple, essentially meaningless hand actions. Such an influence would argue for an intricate neural coupling between action production and action observation, which goes beyond effects of motor r...

We know the human brain contains some kind of clock, but determining its neural underpinnings and teasing apart its components have proven difficult. New work on the parietal cortex illustrates how single unit recording may be able to help.

Studies have shown that improvements in the upper limb function of post-stroke victims tend to be worse than those in the lower limb functions, and there is generally a poorer prognosis for the upper limbs [1]. This is because the upper limbs demand greater involvement of the parietal lobe (surrounding the intraparietal sulcus and the inferior parietal lobule) and the frontal lobe (ventral prem...

Lesion and imaging studies to date have not clarified which sub-regions of the parietal lobe are specialized for arithmetic processing, and which perform supporting functions. We used functional magnetic resonance imaging to investigate parietal lobe function during arithmetic processing. Functional optimization was examined by analyzing regional differences in brain activation between perfect ...