Abstract Introduction Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) is strongly associated with progressive phenoconversion to an overt synucleinopathy (e.g., parkinsonism). Neurotrauma [i.e., traumatic brain injury (TBI) and posttraumatic stress (PTSD)], increases the odds of RBD diagnosis by ~2.5-fold increased later Parkinson’s Disease (PD), a service-connected illness...

Directing stem cells and progenitors towards neuronal differentiation – implications for experimental therapies for Parkinson’s disease Anke Brederlau Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Sahlgrenska Academy at Gothenburg University, Sweden. The insight that stemand progenitor-cells contribute to replacement of nerve cells in the adult central nervous syst...

We propose hypothesis tests for detecting dopaminergic medication response in Parkinson disease patients, using longitudinal sensor data collected by smartphones. The processed data is composed of multiple features extracted from active tapping tasks performed by the participant on a daily basis, before and after medication, over several months. Each extracted feature corresponds to a time seri...

Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with limited functionality.
 However, recent advances highthroughput genomic technology have allowed circRNAs characterized detail and revealed their important functions controlling various ...

Parkinson’s disease is a human disease caused by tolerant disorder of the nervous system that affects movement. It grows slowly, occasionally initiated with a scarcely visible tremor in just one hand. But while a tremor may be the most well-known sign of Parkinson’s disease, the disorder also commonly causes stiffness or slowing of movement. Cluster analysis is an iterative process to modify da...

In addition to dopaminergic neuron loss, it is clear that Parkinson disease includes other pathological changes, including loss of additional neuronal populations. As a means of addressing multiple pathological changes with a single therapeutically-relevant approach, we employed delayed transplantation of a unique class of astrocytes, GDAs(BMP), that are generated in vitro by directed different...

Dopamine (DA) is a major neurotransmitter important for neuroendocrine control and recent studies have described genomic signaling pathways activated and inhibited by DA agonists and antagonists in the goldfish brain. Here we perform a meta-type analysis using microarray datasets from experiments conducted with female goldfish to characterize the gene expression responses that underlie dopamine...

Indeed, before the meeting in Washing-ton DC, these individuals held solid reason for concern. The " adult " stem cell described by Caplan and Pittenger 1,2 as a mesodermal or mesenchymal stem cell had not been widely publicized as a replacement for embryonic stem cells at all. Most hematologists, who by and large controlled the stem cell field, considered these cells to be laboratory artifacts...

Making flexible associations between what we see and what we do is important for many everyday tasks. Previous work in patients with focal lesions has shown that the control of saccadic eye movements in such contexts relies on a network of areas in the frontal cerebral cortex. These regions are reciprocally connected with structures in the basal ganglia although the contribution of these sub-co...