Heat shock proteins (Hsps) play essential protective roles under stress conditions by preventing the formation of protein aggregates and degrading misfolded proteins. EcHsp31, the yedU (hchA) gene product, is a representative member of a family of chaperones that alleviates protein misfolding by interacting with early unfolding intermediates. The 1.6-A crystal structure of the EcHsp31 dimer rev...

The buried hetero-structure (BH) InGaAsP-InP waveguide is used for asystem of double microring resonators (DMR). The light transmission and location ofresonant peaks are determined for six different sets of ring radii with different ordermode numbers. The effect of changing middle coupling coefficient on the box likeresponse is studied. It is found that the surge of coupling coefficient to the ...

The crystal structure of Pseudomonas putida cytochrome P-450cam in the ferric, camphor bound form has been determined and partially refined to R = 0.23 at 2.6 A. The single 414 amino acid polypeptide chain (Mr = 45,000) approximates a triangular prism with a maximum dimension of approximately 60 A and a minimum of approximately 30 A. Twelve helical segments (A through L) account for approximate...

XML tries to bring to natural language documents ("texts" for short), some of what databases have had for decades: explicit structure whose properties can be known; independence of data and structure from reporting (which we foreigners call "formatting"); various kinds of isolation; and so on. But the data buried in those XML elements is weird stuff: deep hierarchies, arbitrary and unpredictabl...

Protein motions are a key feature to understand biological function. Recently, a large-scale analysis of protein conformational diversity showed a positively skewed distribution with a peak at 0.5 Å C-alpha root-mean-square-deviation (RMSD). To understand this distribution in terms of structure-function relationships, we studied a well curated and large dataset of ~5,000 proteins with experimen...

Three implicit solvent models, namely GBMVII, FACTS, and SCPISM, were evaluated for their abilities to emulate an explicit solvent environment by comparing the simulated conformational ensembles, dynamics, and electrostatic interactions of the Src SH2 domain and the Lyn kinase domain. This assessment in terms of structural features in folded proteins expands upon the use of hydration energy as ...

In this study, biodegradation of corn starch/glycerol/Na-MMT nanocomposites by soil burial tests were carried out for up to 6 months. Films were prepared by casting method according to central composite design and response surface methodology was applied for analysis of the results. The effects of formulation on the water solubility, contact angle and tensile strength of starch films were inves...

We analyze the asymptotic behavior of agents engaged in an infinite horizon partially observable stochastic game as formalized by the interactive POMDP framework. We show that when agents’ initial beliefs satisfy a truth compatibility condition, their behavior converges to a subjective ǫ-equilibrium in a finite time, and subjective equilibrium in the limit. This result is a generalization of a ...