In this paper we report on Monte Carlo simulations to investigate real-time monitoring of the track depth profile in particle therapy by measuring prompt gamma ray emissions: a high sensitivity imaging system employing a knife-edge-shaped slit combined with a position-sensitive gamma detector was evaluated. Calculations to test this new concept were performed for a head-sized software phantom. ...

OBJECTIVE To study the efficacy of nebulized topical saline-tobramycin solution in patients with chronic rhinosinusitis refractory to medical and surgical therapy. STUDY DESIGN AND SETTING Twenty patients in whom endoscopic sinus surgery failed to relieve symptoms entered a randomized, double-blind trial of tobramycin-saline solution or saline-only solution administered thrice daily to the na...

This article presents a general discussion on what has been achieved so far and on the possible future developments of targeted alpha (α)-particle therapy (TAT). Clinical applications and potential benefits of TAT are addressed as well as the drawbacks, such as the limited availability of relevant radionuclides. Alpha-particles have a particular advantage in targeted therapy because of their hi...

Double scattering-based proton therapy systems often use patient-specific range compensators for beam modulation. Range compensators adjust the depth in the tissue at which protons reach their Bragg peak. Accurately representing range compensators in Monte Carlo particle transport simulations is a vitally important problem for clinical treatment planning. This paper proposes two new computation...

Development of novel approaches linking the physical characteristics of particles with biological responses are of high relevance for the field of particle therapy. In radiobiology, the clonogenic survival of cells is considered the gold standard assay for the assessment of cellular sensitivity to ionizing radiation. Toward further development of next generation biodosimeters in particle therap...

numerous investigations have been devoted towards understanding the hydrodynamics of gas jets in fluidized beds. however, most of them address the problem from  macroscopic point of view, which does not reveal the true behavior in the jet region at the single particle level. the present work aims to understand the jet behavior from a more fundamental level, i.e. the individual particle level. a...

Nowadays nanotechnology as a new direction of science allows us to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. In Ukraine first preparations of medical nanotechnology were produced and patented in 1998. These are IKBB (intracorporeal biocorrector), magnet-controlled sorbent (MCS-B), and Micromage-B. The preparations ar...

Nowadays nanotechnology as a new direction of science allows us to develop therapeutic methods of the endogenous intoxication syndrome and to create a new class of biocompatible sorbents. In Ukraine first preparations of medical nanotechnology were produced and patented in 1998. These are IKBB (intracorporeal biocorrector), magnet-controlled sorbent (MCS-B), and Micromage-B. The preparations ar...

PURPOSE In ultrasound-guided High Intensity Focused Ultrasound (HIFU) therapy, the target tissue (such as a tumor) often moves and/or deforms in response to an external force. This problem creates difficulties in treating patients and can lead to the destruction of normal tissue. In order to solve this problem, we present a novel method to model and predict the movement and deformation of the t...