نتایج جستجو برای: pbx
تعداد نتایج: 558 فیلتر نتایج به سال:
Platelet factor 4 (PF4) is expressed during megakaryocytic differentiation. We previously reported that GATA-1 and ETS-1 regulate the rat PF4 promoter and transactivate the PF4 gene. For the present study, we investigated the regulatory elements and their transcription factors responsible for the lineage-specific expression of the PF4 gene. The promoter activities of deletion constructs were ev...
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degree. Sporadic and hereditary microphthalmos have been associated with heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identification of molecular causes. Here we show that haploinsufficiency of Meis1, which encodes a transc...
Computer simulations are presented for a Composite Monte Carlo method, which allows direct simulation of 'real' explosives such as HMX and TATB. Chemical equilibrium, solid carbon, fluid-fluid phase separation, and the like, are all included in a single simulation method. Now, the entire detonation products equation of state can be simulated instead of isolated portions for limited benchmarks. ...
The morphogenesis of the vertebrate hindbrain involves the generation of metameric units called rhombomeres (r), and Krox20 encodes a transcription factor that is expressed in r3 and r5 and plays a major role in this segmentation process. Our knowledge of the basis of Krox20 regulation in r3 is rather confusing, especially concerning the involvement of Hox factors. To investigate this issue, we...
Vertebrate appendage patterning is programmed by Hox-TALE factor-bound regulatory elements. However, it remains unclear which cell lineages are commissioned by Hox-TALE factors to generate regional specific patterns and whether other Hox-TALE co-factors exist. In this study, we investigated the transcriptional mechanisms controlled by the Shox2 transcriptional regulator in limb patterning. Harn...
The rational design of effective polymeric binders for the formulation plastic-bonded explosives (PBX) is challenging due to their inherent compositional complexity. composites comprise irregularly shaped energetic material (EM) powders coated with low weight fractions polymer via non-equilibrium processes such as slurry coating. Defects can deleteriously affect PBX stability and performance: n...
در این تحقیق نیتراسیون پلی بوتادیان (pb) با وزن مولکولی پایین، از طریق یک روش معمول و ارزان انجام شد. محصول npb (نیترو پلی بوتادیان) توسط تکنیکهای ft-ir، 1h-nmr، gpc، tga، dsc و ... مورد بررسی قرار گرفت. سپس نرمکننده پلیمری پرانرژی npb به همراه بایندر پلی بوتادیان نیترهشده و خاتمهیافته با هیدروکسیل (nhtpb) به ترتیب جایگزین نرمکننده خنثی دی اکتیل آدیپات (doa) و بایندر پلی بوتادیان خاتمه...
Correct daily phasing of transcription confers an adaptive advantage to almost all organisms, including higher plants. In this study, we describe a hypothesis-driven network discovery pipeline that identifies biologically relevant patterns in genome-scale data. To demonstrate its utility, we analyzed a comprehensive matrix of time courses interrogating the nuclear transcriptome of Arabidopsis t...
The Kruppel-like factor Klf4 is implicated in tumorigenesis and maintaining stem cell pluripotency, and Klf4 can both activate and repress gene expression. We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or GC box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadheri...
Little is known about the molecular mechanisms that integrate anteroposterior (AP) and dorsoventral (DV) positional information in neural progenitors that specify distinct neuronal types within the vertebrate neural tube. We have previously shown that in ventral rhombomere (r)4 of Hoxb1 and Hoxb2 mutant mouse embryos, Phox2b expression is not properly maintained in the visceral motoneuron proge...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید