fms-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. mutations of fms-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. the fms-like tyrosine kinase-3 muta...

Ratios of immunoproteasome over constitutive proteasome expression are an indicator for sensitivity to bortezomib-containing reinduction chemotherapy in pediatric relapsed acute lymphocytic leukemia and acute myeloid leukemia Manuscript in preparation 8 152 ABSTRACT Bortezomib, a proteasome inhibitor, is in Phase 3 clinical trials for the treatment of pediatric acute myeloid leukemia (AML) and ...

Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspects of epigenetics, which control leukemogenesis in pediatric ALL, mainly DNA methylation, histon...

PURPOSE To describe the clinical studies, chemistry manufacturing and controls, and clinical pharmacology and toxicology that led to Food and Drug Administration approval of nelarabine (Arranon) for the treatment of T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. EXPERIMENTAL DESIGN Two phase 2 trials, one conducted in pediatric patients and the other in adult patients, were revie...

Acute lymphoblastic leukemia, acute myeloid leukemia, gingival enlargement. Abstract Most of the systemic diseases manifest signs and symptoms in oral cavity. Periodontal lesions are common in patients with acute leukemia throughout the course of the disease. Although many cases of gingival enlargement in patients with acute myeloid leukemia have been reported in literature, cases of gingival h...

bone marrow specimens from leukemic patients were studied in a 5 year period beginning in 1982 in children's medical center of teheran,a teaching and referral center for pediatric medicine. the slides were stained by giemsa-wright stains, read by at least two persons experienced in bone marrow pathology and classified according to f.a.b. recommendations. peroxidase or sudan black-b and p.a...