Allostatic load (AL) is the cumulative physiological "cost" of prolonged stress. An AL composite measure successfully predicts morbidity and mortality among the elderly but has not been reported in "high stress" samples with posttraumatic stress disorder (PTSD). Accordingly, AL was measured in mothers (ages 29-55) of pediatric cancer survivors and control mothers of healthy children. A signific...

BACKGROUND Obesity has been a growing problem among children and adolescents in the United States for a number of decades. Childhood cancer survivors (CCS) are more susceptible to the downstream health consequences of obesity such as cardiovascular disease, endocrine issues, and risk of cancer recurrence due to late effects of treatment and suboptimal dietary and physical activity habits. OBJ...

There have been numerous reports on survival outcomes after liver transplantation with short-term and mid-term follow-up. However, only a few reports are available for 20-year long-term survivors after liver transplantation. In Korea, the first successful deceased donor liver transplantation (DDLT) in a 13-year-old Wilson's disease patient was performed in 1988, and the first successful living ...

Human septic shock involves multiple genome-level perturbations. We have conducted microarray analyses in children with septic shock within 24 h of intensive care unit admission, using whole blood-derived RNA. Based on sequential statistical and expression filters, there were 2,482 differentially regulated gene probes (1,081 upregulated and 1,401 downregulated) between patients with septic shoc...

Current classifications of pulmonary hypertension have contributed a great deal to our understanding of pulmonary vascular disease, facilitated drug trials, and improved our understanding of congenital heart disease in adult survivors. However, these classifications are not applicable readily to pediatric disease. The classification system that we propose is based firmly in clinical practice. T...

Pediatric solid tumors remain a major health concern, with nearly 16,000 children diagnosed each year. Of those, ~2,000 succumb to their disease, and survivors often suffer from lifelong disability secondary to toxic effects of current treatments. Countless multimodality treatment regimens are being explored to make advances against this deadly disease. One targeted treatment approach is oncoly...

Background Attention and working memory symptoms are among the most common late effects in survivors of pediatric brain tumors, and are often associated with academic and psychosocial difficulties. Diagnostic and treatment approaches derived from the attention-deficit hyperactivity disorder (ADHD) literature have frequently been applied to survivors, yet the extent of overlap in cognitive profi...

OBJECTIVE Long-term survivors of several childhood illnesses are at risk for multiple late effects of their illness or therapy, and children with documented toxic exposures may also experience long-term health consequences. Clinical studies of these effects are difficult to conduct. The Cardiovascular Status in Childhood Cancer Survivors Study is an established study that highlights the ability...