conclusions the determination of warfarin dose, based on genotyping, might reduce the time to achieve stable anticoagulation of warfarin dose and length of hospital stay. patients and methods in this prospective cohort study, 200 pediatric patients, who required warfarin therapy after cardiac surgery, were enrolled and divided into two groups. for 50 cases, warfarin was prescribed based on thei...

BACKGROUND AND OBJECTIVE The safety, tolerability, and pharmacokinetics of the once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide have been evaluated in pediatric patients aged greater than 10 years with type 2 diabetes (T2D). In this study, a population pharmacokinetic analysis was compared to the pediatric pharmacokinetic data with those from two clinical pharmacology trials ...

BACKGROUND In 2010, the World Health Organization revised guidelines to recommend diagnosis of all suspected malaria cases prior to treatment. There has been no systematic assessment of malaria test uptake for pediatric fevers at the population level as countries start implementing guidelines. We examined test use for pediatric fevers in relation to malaria endemicity and treatment-seeking beha...

Clinicians would benefit from decision support systems incorporating the knowledge of clinical practice guidelines. However, the unstructured form of the guidelines makes them unsuitable for formal representation. To remedy this shortcoming we translated a set of pediatric guidelines into Attempto Controlled English (ACE). An experienced pediatrician and a knowledge engineer assessed that ACE c...

2014 There is an increasing prevalence of pediatric hypertension worldwide due to the growing epidemic of childhood obesity. Recent regulatory changes in the USA and Europe have stimulated major pediatric clinical trials of 16 different antihypertensive agents, leading to US FDA labeling of 10 of these drugs. With increased pediatric hypertension trial experience, trial designs have been refine...