Hepatocellular carcinoma has rarely been reported in Wilson's disease, particularly in women. We describe the case of a female patient who was diagnosed with Wilson's disease at the age of 39 years, after presenting with severe neurological symptoms. She had significant neurological improvement following penicillamine therapy and succumbed to hepatocellular carcinoma at the age of 72 years, fol...

The neutral salt-soluble collagen which accumulates in the tissues of animals treated with penicillamine does not differ from normal in amino acid composition, specific optical rotation, and melting temperature. It has higher intrinsic viscosity, possibly due to a contamination with higher molecular weight aggregates originating from the depolymerization of insoluble collagen. In contrast to th...

A case of rheumatoid arthritis, whose presenting problem was a non-infective fistula of the elbow joint, is described. Penicillamine therapy was ineffective, but synovectomy led to healing.

Metal ions accumulate in the brain with aging and in several neurodegenerative diseases. Aside from the copper storage disease, Wilson's disease, recent attention has focused on the accumulation of zinc, copper and iron in the Alzheimer's disease (AD) brain and the accumulation of iron in Parkinson's disease. In particular, the parenchymal deposition of beta-amyloid (Abeta) and its interaction ...

BACKGROUND AND AIMS There are certain areas of uncertainty regarding the best therapeutic approach in patients diagnosed with Wilson Disease (WD). Our aim was to assess treatment response to different therapies in a cohort of WD patients followed in a single center. MATERIAL AND METHODS This is an observational, descriptive study in which clinical, laboratory and imaging data are reviewed in ...