Colcemid (COM) and econazole (EZ) were tested for induction of mitotic arrest and C-mitotic effects in mouse bone marrow cells and for meiotic delay and induction of hyperploidy in mouse spermatocytes after single injection. Doses of 1 and 3 mg/kg COM were used and bone marrow and spermatocytes were sampled at 2, 6, 10, 14 and 18 h. For EZ a dose of 120 mg/kg and intervals of 6, 10, 14 and 18 h...

BACKGROUND Few studies describing eukaryotic communities in the human gut microbiota have been published. The objective of this study was to investigate comprehensively the repertoire of plant and fungal species in the gut microbiota of an obese patient. METHODOLOGY/PRINCIPAL FINDINGS A stool specimen was collected from a 27-year-old Caucasian woman with a body mass index of 48.9 who was livi...

INTRODUCTION Intraosseous infusion is recommended if peripheral venous access fails for cardiopulmonary resuscitation or other medical emergencies. The aim of this study, using body donors, was to compare a semi-automatic (EZ-IO®) device at two insertion sites and a sternal intraosseous infusion device (FASTR™). METHODS Twenty-seven medical students being inexperienced first-time users were r...

Editor’s key points † A new EZ bronchial blocker was compared with double-lumen tube (DLT) for providing single-lung ventilation (SLV). † Forty patients undergoing thoracic surgery were randomized to one of the two groups. † EZ-Blocker (EZ) provided comparable quality of lung collapse to DLT, but took longer for its placement. † EZ will be an efficient alternative for SLV where DLT cannot be us...

the antimicrobial activity of some novel ascorbic acid-metal complexes [bisascorbate complexes of copper (ii), zinc(ii), manganese (11), iron (111), cobalt(ii), lead(ii) and cadmium(ii)] was investigated. four standard strains of bacterial species - staphylococcus aureus, escherichia coli, bacillus subtilis and klebsiella pneumonia and four fungal species - trichophyton sp. penicillium sp., asp...

Purpose To examine outer retinal band changes after flash stimulus and subsequent dark adaptation with ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods Five dark-adapted left eyes of five normal subjects were imaged with 3-μm axial-resolution UHR-OCT during 30 minutes of dark adaptation following 96%, 54%, 23%, and 0% full-field and 54% half-field rhodopsin bleach. We iden...

Compactin (ML-236B) and monacolin K (mevinolin) are specific inhibitors of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthetic pathway1~7). ML-236B was isolated from Penicillium citrinuml) and Penicillium brevicompactum2), and monacolin K from Monascus ruber4) and Aspergillus terreus6). In the present study, approximately 4,000 newly is...

On cycled exposure of Gunn rats to total darkness and low and high illumination, biliary excretion rates of (EZ)- and (ZE)-bilirubin and (EZ)-cyclobilirubin increased up to approx. 10-fold from the mean basal values of 1.2 and 0.2 microgram/h to the mean maximum values of 25.2 and 4.2 micrograms/h respectively, and at the same time those of (EE)-bilirubin and (EE)-cyclobilirubin also increased,...