BACKGROUND The protein transduction domain (PTD) enables therapeutic proteins to directly penetrate the membranes of cells and tissues, and has been increasingly utilized. Glutaredoxin-1 (GRX-1) is an endogenous antioxidant enzyme involved in the cellular redox homeostasis system. In this study, we investigated whether PEP-1-GRX-1, a fusion protein of GRX-1 and PEP-1 peptide, a PTD, could suppr...

Este trabalho tem como título Perfil Epidemiológico De Adesão Pacientes Pós-Exposição Na Região Norte Do Brasil, onde o intuito foi buscar um total de pessoas que iniciaram tratamento da PEP (profilaxia pós exposição), verificar a adesão e descrever perfil epidemiológico dos pacientes com indicação 2018 2022. Para isso, definimos objetivo geral determinar expostos ao vírus do HIV na região nort...

We report the direct measurement of electrical transport through rod-like polymer molecules, of poly(ethyl propiolate) (PEP), utilizing single walled carbon nanotubes (SWNTs) as electrodes. The electrical properties of the devices were measured (i) before cutting a SWNT, (ii) when a SWNT was cut and (iii) after PEP deposition into the nanoscale gap in a cut SWNT. The gate-dependent electrical p...

Post-transcriptional control is nowadays considered a main checking point for correct gene regulation during development, and RNA binding proteins actively participate in this process. Arabidopsis thaliana FLOWERING LOCUS WITH KH DOMAINS (FLK) and PEPPER (PEP) genes encode RNA-binding proteins that contain three K-homology (KH)-domain, the typical configuration of Poly(C)-binding ribonucleoprot...

AIM To detect risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) and investigate the predictors of its severity. METHODS This is a prospective cohort study of all patients who underwent ERCP. Pre-ERCP data, intraoperative data, and post-ERCP data were collected. RESULTS The study population consisted of 996 patients. Their mean age at presentation...

Corynebacterium glutamicum possesses phosphoenolpyruvate (PEP) carboxykinase, oxaloacetate decarboxylase and malic enzyme, all three in principle being able to catalyze the first step in gluconeogenesis. To investigate the role of PEP carboxykinase for growth and amino acid production, the respective pck gene was isolated, characterized and used for construction and analysis of mutants and over...

The 125 kW CW klystrons to be described in the first part of this paper were specifically designed for energy upgrading of the electron-positron storage ring, SPEAR II, at SLAC. Four tubes are required with an efficiency greater than 50 percent. The operating frequency is 358.54 MHz. The gain is approximately 50 dB, the operating voltage is 41 kV and the microperveance is 0.7. The klystron must...

Although some individuals who present for antiretroviral postexposure prophylaxis (PEP) had a 1-time exposure to human immunodeficiency virus (HIV), others may be recurrently risky. Given that preexposure prophylaxis (PrEP) has been shown to be efficacious, identification of those individuals who present for PEP who might benefit from PrEP is important to decrease HIV acquisition in high-risk i...

As FK506 binding proteins (FK506BPs) are known to play an important role in the regulation of a variety of biological processes related to cell survival, this study was designed to examined the protective effects of FK506 binding protein 12 (FK506BP) on low humidity air flow induced dry eye in a rat model using transduced PEP-1-FK506BP. After the topical application of PEP-1-FK506BP, tear volum...