methenamine salts have been traditionally used in the veterinary and human medicine, but its use is sometimes associated with some side effects.toxicopathological effects of methenamine salt have always been a major concern. there is scantly information available about the lesions of methenamine compound in embryo. the objective of this study was to determine the teratogenic effects of methenam...

Cerebro vascular CO2 Reactivity of the Fast and Slow Clearing Compartments • Regional cerebral blood flow measurements have been made at two levels of Paco, using the clearance of Xenon injected into the internal carotid artery. Specific and percent changes in blood flow per mm Hg change in Paco, (CO2 reactivity) have been calculated for the fast and slow clearing tissue (Ff and Fs) and F initi...

OBJECTIVES Our aim was to image angiogenesis produced by endomyocardial injection of phVEGF165 in a swine model of hibernating myocardium using [123I]Gluco-arginine-glycine-aspartic acid (RGD) targeting the alphavbeta3 integrins. BACKGROUND A noninvasive test to monitor the efficacy of therapy inducing angiogenesis is needed. The interaction between extracellular matrix and endothelial cells ...

Clinical signs, para-clinical tests and gross lesion can be used for identification of parasite contamination. In most parasite contamination the clinical signs are not obvious. Thus, para-clinical tests and gross lesion play important roles in identifying parasite disease as all organs of animals such as skin, eyes, kidneys, liver and digestive tube can be affected by the parasites. Consequent...

BACKGROUND The use of high-dose adjuvant chemotherapy for high-risk primary breast cancer is controversial. We studied its efficacy in patients with 4 to 9 or 10 or more tumor-positive axillary lymph nodes. METHODS Patients younger than 56 years of age who had undergone surgery for breast cancer and who had no distant metastases were eligible if they had at least four tumor-positive axillary ...

UNLABELLED Annexin V, a human protein with a high affinity for phosphatidylserine, has been labeled with (99m)Tc to detect apoptosis in vivo. To determine the effectiveness of imaging with this agent as a reflection of the degree of apoptosis after the first dose of chemotherapy, we studied rats with an engrafted hepatoma. METHODS Annexin V was labeled with (99m)Tc (specific activity, 3.0 MBq...

The paper studies the effect of RVI biocomposite material belonging to group osteoplastic materials, RV-2 immunomodulator – a synthetic dipeptide inducing an immunocorrective effect, and combinations these drugs on reparative histogenesis bone tissue in femoral fractures rats. It was found that remodeling primary callus into secondary one fracture studied animals diverse nature. This process mo...

BACKGROUND Lectins (proteins that bind specific sugar molecules on glycoproteins and glycolipids) are expressed at various levels on the surface of tumor cells. Conjugation of cytotoxic agents to glycoproteins recognized by lectins could be useful in the treatment of tumors. Avidin (a highly glycosylated, positively charged protein found in egg white) contains terminal N-acetylglucosamine and m...

neurokinin 1 receptors (nk1r) are overexpressed on several types of important human cancer cells. substance p (sp) is the most specific endogenous ligand known for nk1rs. accordingly, a new sp analogue was synthesized and evaluated for detection of nk1r positive tumors. [6-hydrazinopyridine-3-carboxylic acid (hynic)-tyr8-met(o)11-sp] was synthesized and radiolabeled with 99mtc using ethylenedia...