New advances in interventional cardiology and antithrombotic pharmacological treatment have modified the risk:benefit ratio of percutaneous interventions in acute coronary syndromes without ST segment elevation. In general terms, invasive strategies have two main limitations. The first stems from the fact that the severity of a coronary stenosis is not an index of the likelihood of the developm...

Endothelial dysfunction is an important pathomechanism of atherosclerosis. Among other things, it may be responsible both for a late outcome of lower extremity revascularization and occurrence of cardiovascular events in this high risk patient population. There are some papers available which show that improvement in leg perfusion, both after percutaneous or surgical intervention, may improve e...

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...

Stenosing tenosynovitis of the thumb and fingers is a very common problem seen by the primary-care physician, the orthopaedic surgeon, and the hand surgeon. Primary stenosing tenosynovitis is usually idiopathic and occurs more frequently in middle-aged women than in men, but can be seen even in infancy. Secondary stenosing tenosynovitis of the digits can occur in patients with rheumatoid arthri...

Achieving frontal plane alignment of the ankle joint during primary and revision total ankle replacement is essential for long-term success. This manuscript presents the revision of a failed AgilityTM LP total ankle replacement system with severe > 40° varus ankle deformity that was corrected with explanation and conversion to an INBONETM II total ankle system coupled with soft-tissue release/r...

Department of Cardiology, Heart Hospital, 16–18 Westmoreland Street, London, W1G 8PH, UK In percutaneous coronary interventions the main risk of restenosis and, despite the advent of drugeluting stents, it still poses a significant problem [1]. The concept behind drug-eluting balloons (DEBs) is local drug administration and sustained release of antiproliferative drugs without a permanent stent ...