نتایج جستجو برای: peripheral mononuclear cell pbmc

تعداد نتایج: 1813954  

Journal: :Oncology reports 2002
M Lazarczyk T Grzela G Korczak-Kowalska J Niderla M Oldak J Jozwiak P Skopinski

Pentoxifylline (PTX) is commonly used in peripheral blood vessel diseases, however it has also been found to decrease the level of proinflammatory cytokines such as IL-12, TNF-alpha and IFN-gamma. Moreover, some authors reported that PTX suppresses spontaneous cytotoxicity of peripheral blood mononuclear cells (PBMC) in vitro. It could influence the mechanism of killing target cells by PBMC. Fo...

Journal: :Transplantation 1988
R F Raff E Severns R Storb P Martin T Graham B Sandmaier F Schuening G Sale F R Appelbaum

Incubation of canine marrow and peripheral blood mononuclear cells with L-leucyl-L-leucine methyl ester resulted in the inhibition of mitogen- and alloantigen-induced blastogenesis, the elimination of allosensitized CTL and NK activity, and prevented the development of CTL from pCTL. The effects of these incubations were similar to those described in mice and humans. Additionally, in vitro CFU-...

Journal: :Mediators of Inflammation 2002
Sergey V Kalashnikov Elena A Kalashnikova Svetlana N Kokarovtseva

Benzodiazepines (BDZs) are known to act not only in the central nervous system, but on peripheral cells and tissues binding to the peripheral-type benzodiazepine receptors. In the present study, the influence of two different BDZs (diazepam (Dz) and tofizopam (Tof) on several immune functions has been examined in vitro. Some differences between Dz and Tof in their effects on human lymphocyte pr...

2000
Gabriele A. Losa Riccardo Graber

Peripheral blood mononuclear cells (PBMC) from 251 HIV-positive drug abusers of known clinical stage and from 40 healthy donors were tested for conventional immunologic markers (CD3, CD4, CD8, CD19, CD14, CD16/CD56, CD45 and HLA-DR). Additional cell parameters and the occurrence of spontaneous apoptosis (programmed cell death) were investigated on freshly isolated PBMC by flow cytometric measur...

2012
Shounan Yi Ming Ji Jingjing Wu Xiaoqian Ma Peta Phillips Wayne J. Hawthorne Philip J. O’Connell

T cell-mediated rejection remains a barrier to the clinical application of islet xenotransplantation. Regulatory T cells (Treg) regulate immune responses by suppressing effector T cells. This study aimed to determine the ability of human Treg to prevent islet xenograft rejection and the mechanism(s) involved. Neonatal porcine islet transplanted NOD-SCID IL2rγ(-/-) mice received human peripheral...

2013
T Bogoslovsky D Wang D Maric L Scattergood-Keepper M Spatz S Auh J Hallenbeck

BACKGROUND Endothelial progenitor cells (EPC) are markers of endothelial injury and may serve as a surrogate marker for vascular repair in interventional clinical trials. Objectives of this study were to modify a method of isolation of peripheral blood mononuclear cells (PBMC) and enumeration of EPC and mature endothelial cells (EC) from peripheral blood and to evaluate influence of cryopreserv...

Journal: :Blood 1991
T Pietsch C Bührer K Mempel T Menzel U Steffens C Schrader F Santos C Zeidler K Welte

Severe congenital neutropenia (SCN) is a disorder of myelopoiesis characterized by severe neutropenia or absence of blood neutrophils secondary to a maturational arrest at the level of promyelocytes. We examined peripheral blood mononuclear cells (PBMC) of SCN patients who demonstrated normalization of their blood neutrophil counts in a phase II clinical study with recombinant human granulocyte...

Journal: :Journal of clinical microbiology 1993
P G Reddy W J Sapp W Heneine

Detection of caprine arthritis-encephalitis virus (CAEV) infection in goats is currently limited to serologic testing or cell culture. We developed a polymerase chain reaction (PCR) assay to detect CAEV sequences in peripheral blood mononuclear cells (PBMC), synovial fluid cells (SFC), and milk cells (MC) obtained from infected goats. Results were positive for 18 of 20 PBMC, 8 of 8 MC, and 5 of...

ژورنال: کومش 2017
آقا بیگی, آرش, شکراللهی باروق, مهدیه, فرانوش, محمد, قهرمان فرد, فرحناز, منوچهری, احسان, میر محمدخانی, مجید, پاشایی, مهرنوش, پاک, فاطمه, کوخایی, پرویز,

هدف:لوسمی لنفوئیدیمزمن (Chronic lymphocytic leukemia, CLL) یکی از شایع‌ترین بدخیمی‌های لنفوئیدی در کشورهای غربی است. به‌طور عموم افراد مسن از طریق تجمع و تکثیر لنفوسیت‌هایB که دارای مارکرهایCD19+، CD20+،CD5+وCD23+ هستند، درگیر می‌کند. بربرین ازجمله ترکیبات طبیعی با ساختار ایزوکویئلون آلکالویید است که دارای توانایی بالقوه ضد سرطانی می‌باشد. در شرایط آزمایشگاهی بربرین در رده‌های سلول‌های سرطانی ...

Journal: :Cytometry. Part A : the journal of the International Society for Analytical Cytology 2016
Kim L Weisgrau Moritz Ries Nicholas Pomplun David T Evans Eva G Rakasz

This panel was developed to measure the functional capability of natural killer (NK) cell subsets in rhesus macaques (Macaca mulatta). It includes markers to determine the frequency of cytokine secreting and cytotoxic NK cell subpopulations in peripheral blood mononuclear cell (PBMC) samples stimulated in vitro with human 721.221 cells. NK cell subsets were defined by the expression of killer c...

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