The use of high-volume i.p. chemotherapy with methotrexate (7.5 to 50 microM methotrexate administered via peritoneal dialysis technique) was studied in four patients with ovarian cancer and one patient with malignant melanoma. All had tumor localized to the peritoneal cavity or liver. Methotrexate concentration in the peritoneum could be maintained 18- to 36-fold higher than corresponding plas...

BACKGROUND The optimal treatment of peritoneal carcinomatosis of colorectal origin appears to be a combination of systemic chemotherapy and complete surgical cytoreduction with synchronous intraperitoneal chemotherapy. The aim of this study was to assess the feasibility of, and outcomes following, surgical treatment and systemic chemotherapy alone. METHODS Prospectively collated data from the...

A patient presenting an unusual clinical picture was recently admitted to the New Haven Hospital. She showed definite objective evidence of involvement of the central nervous system, but other obscure signs present made an accurate diagnosis difficult. At necropsy a most unexpected lesion was found involving the base of the brain, the nerve roots, and the spinal cord. The case is of particular ...

Background: One of uncommon complications in patients with peritoneal catheter is colon rupture which usually occurs during catheter insertion. In this paper, we present a case of delayed perforated colon following insertion of peritoneal catheter. Case presentation: A 37-year-old man was suffering from chronic renal failure (CRF). Nine months after peritoneal catheterization, peritoneal dialy...

Four patients are described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. It is possible that the initial thyroid neoplasm was a well- differentiated follicular carcinoma which was microscopically indistinguishable from a benign adenoma. Realizing this pathologic pitfall in thyroid diagnosis, the need for meticulous examination of the pa...