Sustained inward currents in neuronal membranes underlie tonic-clonic seizure discharges and spreading depression (SD). It is not known whether these currents flow through abnormally operating physiological ion channels or through pathological pathways that are not normally present. We have now used the NEURON simulating environment of Hines, Moore, and Carnevale to model seizure discharges and...

One important area for which little experimental evidence is available is the snowgrass country. There is a strong body of opinion that in the snowgrass the combined effects of fire and grazing have been responsible for deterioration in vegetative cover and stability. It seems likely that changes in the boundari~s between the snowgrass and fescue communiti~s have been due to, or aggravated by, ...

Here we describe a browser that provides a two and a half dimensional viewing mechanism for persistent data structures. The browser is an adaptive program which learns about its environment; this knowledge is stored in the persistent object store. It achieves this by making use of a compiler that is a dynamically callable data object in the environment. Other novel features of the design of the...

Editorial Persistent vegetative state, withdrawal of artificial nutrition and hydration, and the patient's "best interests" In this issue of the journal Anthea Fenwick, an Edinburgh University graduate law student, robustly challenges the use of "best interests" by English judges in the context of permitting withdrawal of life-supporting nutrition and hydra-tion from patients in persistent vege...

Converging research suggests that the resting brain operates at the cusp of dynamic instability, as signified by scale-free temporal correlations. We asked whether the scaling properties of these correlations differ between amplitude and phase fluctuations, which may reflect different aspects of cortical functioning. Using source-reconstructed magneto-encephalographic signals, we found power-la...

Phaidra (Permanent Hosting, Archiving and Indexing of Digital Resources and Assets ) is used as a long-term preservation system through the assignment of persistent identifiers (permanent links). The project was launched in 2006 and is the successful result of cooperation between the Vienna University Computer Center, the Center for Teaching and Learning and the Vienna University Library. At pr...