Colon targeted delivery systems of metronidazole (MTZ) based on osmotic technology were developed. The developed systems consisted of osmotic core (drug, osmotic agent and wicking agent), coated with semipermeable membrane (SPM) containing guar gum as pore former, coated core were then further coated with enteric coating to protect the system from acidic environment of stomach. The effect of va...

The basic ingredients of osmotic pressure are a solvent fluid with a soluble molecular species which is restricted to a chamber by a boundary which is permeable to the solvent fluid but impermeable to the solute molecules. For macroscopic systems at equilibrium, the osmotic pressure is given by the classical van’t Hoff Law, which states that the pressure is proportional to the product of the te...