A novel amphiphilic pH-sensitive triblock polymer brush (poly(β-amino esters)-g-cholesterol)-b-poly(ethylene glycol)-b-(poly(β-amino esters)-g-cholesterol) ((PAE-g-Chol)-b-PEG-b-(PAE-g-Chol)) was designed and synthesized successfully through a three-step reaction, and their self-assembled polymeric micelles were used as hydrophobic anticancer drug delivery carriers to realize effectively contro...

Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of such In this work, gellan gum-based was optimized using coaxial air flow method, an inexpensive reproducible method. A design experiments used identi...

5-ASA is widely used for its local effects in the treatment of inflammatory bowel diseases (Loftus, 2004). Because of the 4-aminophenol structure and antioxidative properties it is considered as a light, temperature and oxygen sensitive drug and its major degradation products are well established (Jensen, 1992). As a zwitter ion, dominantly anionic, 5-ASA has low aqueous solubility and it is po...

BACKGROUND AND THE PURPOSE OF THE STUDY Many drugs which have narrow therapeutic window and are absorbed mainly in stomach have been developed as gastroretentive delivery system. Rosiglitazone maleate, an anti-diabetic, is highly unstable at basic pH and is extensively absorbed from the stomach. Hence there is a need to develop a gastroretentive system. In this study a superporous hydrogel was ...

Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA nanoparticles are coated by polyelectrolytes using the layer-by-layer self-assembly techni...

Introduction Wound pH influences residence time and activity of growth factors in healing [1]. Hence, pH responsive sustained release growth factor delivery system capable of modulating release pattern in response to varying wound pH is beneficial for treatment of wound. Thus, potential of poly (N-iso propylacrylamide-co-acrylic acid) hydrogel as pH sensitive sustained release system for wound ...

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

HN Shivakumar, et al., (2007), Fabricated & evaluation of pH sensitive Minitablets for chronotherapeutic delivery of theophylline using different coat weights of eudragit S-100 to be applied to the drug loaded core mini-tablets. The study showed that the coat weight of 10% weight gain was sufficient to impart an excellent gastro resistant property to the tablets for effective release of the dru...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...